The people behind the papers - Maria Avdeeva, Madeline Chalifoux and Eszter Posfai.

IF 3.6 2区生物学 Q1 DEVELOPMENTAL BIOLOGY

Development Pub Date : 2025-09-01 Epub Date: 2025-09-05 DOI:10.1242/dev.205160

引用次数: 0

Abstract

During pre-implantation development of the mouse embryo, cells must undergo their first fate decision. While key regulators of this process are known, the variability in lineage trajectories within and between embryos during this stage of development remain poorly understood. In a new study, Avdeeva and colleagues used Bayesian modelling to understand the dynamics of key regulators YAP, SOX2 and CDX2 in this cell fate decision and characterise the variability in this system. To find out more, we spoke to co-first authors Maria Avdeeva and Madeline Chalifoux, and corresponding author Eszter Posfai, Assistant Professor at Princeton University, USA.

查看原文本刊更多论文

这些报纸背后的人——玛丽亚·阿夫季娃，玛德琳·查利福和埃斯特·波斯特菲。

在小鼠胚胎的植入前发育过程中，细胞必须经历它们的第一次命运决定。虽然这一过程的关键调控因子是已知的，但在这一发育阶段胚胎内部和胚胎之间的谱系轨迹的可变性仍然知之甚少。在一项新的研究中，Avdeeva及其同事使用贝叶斯模型来理解关键调控因子YAP、SOX2和CDX2在细胞命运决定中的动态，并描述了该系统的可变性。为了了解更多，我们采访了共同第一作者Maria Avdeeva和Madeline Chalifoux，以及通讯作者，美国普林斯顿大学助理教授Eszter Posfai。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

期刊介绍： Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community. Development includes a Techniques and Resources section for the publication of new methods, datasets, and other types of resources. Papers describing new techniques should include a proof-of-principle demonstration that the technique is valuable to the developmental biology community; they need not include in-depth follow-up analysis. The technique must be described in sufficient detail to be easily replicated by other investigators. Development will also consider protocol-type papers of exceptional interest to the community. We welcome submission of Resource papers, for example those reporting new databases, systems-level datasets, or genetic resources of major value to the developmental biology community. For all papers, the data or resource described must be made available to the community with minimal restrictions upon publication. To aid navigability, Development has dedicated sections of the journal to stem cells & regeneration and to human development. The criteria for acceptance into these sections is identical to those outlined above. Authors and editors are encouraged to nominate appropriate manuscripts for inclusion in one of these sections.