Søren L Jacobsen, Christian L Kraft, Andrew A Nierenberg, Torben A Devantier, Ole Köhler-Forsberg
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引用次数: 0
Abstract
Background: Lithium blood levels are measured routinely 12 h after lithium dosing, but no study has evaluated the actual compliance of patients with the 12-h levels.
Methods: First, we used the US multicenter clinical trial "Bipolar CHOICE" (n = 145 patients treated with lithium with N = 287 lithium blood tests), where participants reported the time since the last lithium dose at lithium blood tests. Second, we included all lithium blood tests (3179 individuals, 52,837 blood tests) from hospitals and private practitioners in the Central Denmark Region (CDR, approximate population 1.3 million) during 2012-2022, including the time of lithium blood tests and the registered time when patients were supposed to take their lithium dose.
Results: In Bipolar CHOICE, participants took the lithium blood test at a mean/median of 12.8/12 h (SD = 9.1, IQR = 10.5-14) after the lithium dose, but the range was 0.5-120 h and 44.9% had the blood test taken < 10 or > 14 h after the lithium dose. Those with a blood test > 14 h after the lithium dose had significantly lower lithium levels (0.41 vs. 0.64). In the CDR, the mean/median time was 14.5/13.7 (SD = 3.8, IQR = 12.0-15.8) and 49.7% had the blood test taken < 10 or > 14 h after the supposed intake of lithium. Those with > 16 h between lithium intake and the lithium blood test were more often followed by general practitioners and showed higher creatinine concentrations.
Conclusions: Approximately half of lithium blood tests do not comply with guideline-based recommendations for 12-h trough levels, emphasizing the need for solutions to solve this clinical need.
期刊介绍:
Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas:
biochemistry
physiology
neuropsychopharmacology
neuroanatomy
neuropathology
genetics
brain imaging
epidemiology
phenomenology
clinical aspects
and therapeutics of bipolar disorders
Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders.
The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.