Metal ions and colorectal cancer: unlocking the secrets of tumour cell death.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-09-05 DOI:10.1080/13813455.2025.2556008

Yuhao Yu, Jiayan Luo, Haizhong Jiang, Haojun Song, Bujiang Wang

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引用次数: 0

Abstract

Background: Colorectal cancer (CRC) is a highly prevalent and fatal malignancy worldwide. Despite advancements in early screening techniques and treatments, the prognosis for patients remains suboptimal. Studies have shown that metal ions play crucial roles in the occurrence, progression, and treatment of CRC.

Method: Regulating the concentrations of specific metal ions within tumour cells can promote cancer cell death and increase the effectiveness of chemotherapy, radiotherapy, targeted therapy, and immunotherapy.

Results: This article reviews the relationships between metal ions such as iron, copper, potassium, calcium, magnesium, and zinc and CRC, summarising recent research progress from mechanistic studies to clinical applications. Magnesium ions inhibit CRC development and metastasis by regulating various signalling pathways can either promote or inhibit tumour-associated gene expression.

Conclusion: Therefore, modulating the concentrations of relevant metal ions within tumour cells could be a potential therapeutic direction for CRC, providing new theoretical foundations and strategies for clinical treatment.

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金属离子与结直肠癌：解开肿瘤细胞死亡的秘密。

背景：结直肠癌（Colorectal cancer， CRC）是世界范围内发病率高、致死性强的恶性肿瘤。尽管早期筛查技术和治疗取得了进步，但患者的预后仍然不理想。研究表明，金属离子在结直肠癌的发生、发展和治疗中起着至关重要的作用。方法：调节肿瘤细胞内特定金属离子的浓度可促进癌细胞死亡，提高化疗、放疗、靶向治疗和免疫治疗的有效性。结果：本文综述了铁、铜、钾、钙、镁、锌等金属离子与结直肠癌的关系，综述了近年来从机制研究到临床应用的研究进展。镁离子通过调节多种信号通路抑制结直肠癌的发展和转移，可促进或抑制肿瘤相关基因的表达。结论：因此，调节肿瘤细胞内相关金属离子的浓度可能是CRC的潜在治疗方向，为临床治疗提供新的理论基础和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.