Cross-sectional study on the connection between collateral status and cognitive impairment after stroke based on neural regulation and protein metabolism.

IF 2.7 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Shufen Zhang, Jiwei Cheng, Chuansen Liu, Yunyun Zhang
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引用次数: 0

Abstract

Background: Post-stroke cognitive impairment (PSCI), a common complication following stroke, significantly impacts patients' quality of life and prognosis. Research indicates that neuroregulation and protein metabolic disorders play crucial roles in the development of PSCI.

Purpose: This study aimed to evaluate the reliability of the Regional Meningoarterial Score (rLMC) in determining collateral circulation status in acute ischaemic stroke patients.

Method: Participants were selected based on specific criteria including MRI-detected recent cerebral infarction, absence of prior large-scale subcortical infarction or haemorrhage, and no history of Alzheimer's disease or cognitive impairment.

Results: The results showed that cognitive impairment group (CI group) exhibited significantly lower serum acetylcholine levels compared to normal control group (CN group), while β-amyloid protein levels were markedly higher. CI group also demonstrated reduced expression of neuroregulatory factors.

Conclusion: These findings demonstrate that neuroregulatory factors and protein metabolites can serve as potential biomarkers for early diagnosis and intervention, effectively predicting post-stroke cognitive impairment.

基于神经调节和蛋白质代谢的脑卒中后侧支状态与认知功能障碍关系的横断面研究。
背景:脑卒中后认知障碍(PSCI)是脑卒中后常见的并发症,严重影响患者的生活质量和预后。研究表明,神经调节和蛋白质代谢紊乱在PSCI的发展中起着至关重要的作用。目的:本研究旨在评估区域脑膜动脉评分(rLMC)在确定急性缺血性脑卒中患者侧支循环状态方面的可靠性。方法:根据特定标准选择参与者,包括mri检测到的近期脑梗死,既往无大面积皮质下梗死或出血,无阿尔茨海默病或认知障碍史。结果:认知障碍组(CI组)血清乙酰胆碱水平明显低于正常对照组(CN组),β-淀粉样蛋白水平明显高于正常对照组(CN组)。CI组神经调节因子表达降低。结论:神经调节因子和蛋白质代谢产物可作为早期诊断和干预的潜在生物标志物,有效预测脑卒中后认知障碍。
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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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