Exploring therapeutic potential of Cannabis based therapy in autoimmune and rheumatic disorders

IF 8.3 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-09-02 DOI:10.1016/j.autrev.2025.103925

Inbar Michaeli , Simon Lassman , Gilad Halpert , Giris Jacob , Howard Amital

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引用次数: 0

Abstract

The medical use of cannabis is expanding across many countries, with some legalizing its use outright and others implementing medical licensure systems to approve treatment for eligible patients.

Despite this growing interest and utilization, there remains a lack of solid scientific evidence supporting its medical use, even though cannabis has been used therapeutically for thousands of years.

The goal of the following communication is to present updated data on the potential roles of cannabis-based treatments in various autoimmune and rheumatic conditions. The information highlights that incorporating cannabis into the therapeutic armamentarium may offer benefits. However, in many cases, despite encouraging perspectives and outcomes, the supporting evidence remains insufficient and requires further validation.

Due to social and legal barriers, the conduct of such rigorous clinical trials has been hindered, limiting the availability of high-quality evidence to guide medical practice.

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探索大麻治疗自身免疫性疾病和风湿病的治疗潜力。

大麻的医疗用途正在许多国家扩大，一些国家将其使用完全合法化，另一些国家实施医疗执照制度，批准对符合条件的患者进行治疗。尽管人们对大麻的兴趣和利用日益增加，但尽管大麻用于治疗已有数千年的历史，但仍然缺乏支持其医疗用途的可靠科学证据。以下通讯的目的是提供关于大麻治疗在各种自身免疫性和风湿病中的潜在作用的最新数据。该信息强调，将大麻纳入治疗手段可能会带来好处。然而，在许多情况下，尽管观点和结果令人鼓舞，但支持性证据仍然不足，需要进一步验证。由于社会和法律障碍，这种严格的临床试验的进行受到阻碍，限制了指导医疗实践的高质量证据的获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.