Kayla D Mashoudy, Joselyn Ye-Tay, Sarah Kim, Nicole Khalil, Gil Yosipovitch
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引用次数: 0
Abstract
Lichen simplex chronicus is a chronic pruritic skin condition that significantly impacts quality of life. This retrospective study analysed 125 patients with clinically confirmed lichen simplex chronicus seen at a tertiary academic centre to characterize itch severity, anatomical distribution, and associated comorbidities. Itch intensity was assessed using the Numerical Rating Scale (NRS), and clinical data were stratified by demographics and disease extent. Most patients (75%) reported moderate-to-severe itch (NRS 4-10), with nearly 90% experiencing daily pruritus and half reporting both daytime and nocturnal symptoms. The limbs were the most commonly affected sites. Comorbid conditions were frequent, including generalized anxiety disorder (50% vs ~3% in the US adult population), major depressive disorder (44% vs ~8%), hypertension (61% vs ~45%), and type 2 diabetes (30% vs ~11%). Patients with multiple-lesion lichen simplex chronicus had significantly higher itch severity (mean NRS 7.81 vs 7.08, p = 0.001) and were more likely to be female (81% vs 46%, p = 0.002) compared with those with localized disease. These findings highlight the high symptom burden and frequent co-occurrence of psychiatric and metabolic comorbidities in lichen simplex chronicus. Thus, early identification and management of psychiatric, neurological, and metabolic conditions may improve outcomes for patients with lichen simplex chronicus.
慢性单纯性地衣是一种严重影响生活质量的慢性瘙痒性皮肤病。本回顾性研究分析了在三级学术中心就诊的125例临床确诊的慢性单纯地衣患者,以表征瘙痒严重程度、解剖分布和相关合并症。瘙痒强度采用数值评定量表(NRS)评估,临床数据按人口统计学和疾病程度分层。大多数患者(75%)报告中度至重度瘙痒(NRS 4-10),近90%的患者每天都有瘙痒,一半的患者报告白天和夜间都有症状。四肢是最常见的受累部位。合并症很常见,包括广泛性焦虑症(50% vs ~3%)、重度抑郁症(44% vs ~8%)、高血压(61% vs ~45%)和2型糖尿病(30% vs ~11%)。多病变慢性单纯地衣患者的瘙痒严重程度明显高于局限性疾病患者(平均NRS为7.81 vs 7.08, p = 0.001),且女性患者比例更高(81% vs 46%, p = 0.002)。这些发现突出了慢性单纯地衣病的高症状负担和频繁的精神和代谢合并症。因此,早期识别和管理精神、神经和代谢状况可能改善慢性单纯地衣患者的预后。
期刊介绍:
Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.