Diagnostic Challenges and Influencing Factors in Non-Melanoma Skin Cancers: A Retrospective Analysis of Basal Cell Carcinoma and Squamous Cell Carcinoma Cases

IF 1.9 Q4 ONCOLOGY

Cancer reports Pub Date : 2025-09-04 DOI:10.1002/cnr2.70332

Nicholas Florin Kormos, Ioana Daria Paval, Carina Maria Petrenciu, Alin Stefan Vizitiu, Adrian Lucian Baican

{"title":"Diagnostic Challenges and Influencing Factors in Non-Melanoma Skin Cancers: A Retrospective Analysis of Basal Cell Carcinoma and Squamous Cell Carcinoma Cases","authors":"Nicholas Florin Kormos, Ioana Daria Paval, Carina Maria Petrenciu, Alin Stefan Vizitiu, Adrian Lucian Baican","doi":"10.1002/cnr2.70332","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Non-melanoma skin cancers (NMSC) are the most frequent cutaneous tumors globally. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represent the most frequently encountered representatives of this group and may represent a diagnosis challenge in some circumstances of hard to differentiate tumors.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>The aim of this study was to determine the factors that influence the diagnosis of NMSC and their impact.</p>\n </section>\n \n <section>\n \n <h3> Methods and Results</h3>\n \n <p>A single center, descriptive, retrospective study was performed, with a total of 866 tumors excised from 678 patients between 2016 and 2022. Cases were then analyzed based on their histological diagnosis and characteristics and the available clinical data. From the 866 cases, 709 were histologically diagnosed as BCC and 157 as SCC. The clinical accuracy for BCCs was 95% whereas for SCCs was 62% with both having large variations among attending dermatologists. Clinical factors that were found to influence the diagnosis were: advanced age (<i>p</i> ⟨ 0.001), a biopsy beforehand (<i>p</i> = 0.009), and multiple diagnosis or uncertainty (<i>p</i> = 0.005) were predictive for a final diagnosis of SCC. Factors predicting BCCs were: the presence of multiple lesions (<i>p</i> = 0.032), presence of ulcerations (<i>p</i> ⟨ 0.001), age under 50 (<i>p</i> = 0.002). BCCs were more likely to be correctly diagnosed than SCC (<i>p</i> ⟨ 0.001). Cases with multiple BCCs were thinner compared to single-lesion excisions (<i>p</i> ⟨ 0.001). A tumor reduction was observed after the 2020 the SARS-CoV-2 (<i>p</i> = 0.023).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Differentiating NMSC can be challenging, but several trends have been observed which may aid in further improving the diagnosis rates especially for SCCs.</p>\n </section>\n </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 9","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70332","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cnr2.70332","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Non-melanoma skin cancers (NMSC) are the most frequent cutaneous tumors globally. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represent the most frequently encountered representatives of this group and may represent a diagnosis challenge in some circumstances of hard to differentiate tumors.

Aims

The aim of this study was to determine the factors that influence the diagnosis of NMSC and their impact.

Methods and Results

A single center, descriptive, retrospective study was performed, with a total of 866 tumors excised from 678 patients between 2016 and 2022. Cases were then analyzed based on their histological diagnosis and characteristics and the available clinical data. From the 866 cases, 709 were histologically diagnosed as BCC and 157 as SCC. The clinical accuracy for BCCs was 95% whereas for SCCs was 62% with both having large variations among attending dermatologists. Clinical factors that were found to influence the diagnosis were: advanced age (p ⟨ 0.001), a biopsy beforehand (p = 0.009), and multiple diagnosis or uncertainty (p = 0.005) were predictive for a final diagnosis of SCC. Factors predicting BCCs were: the presence of multiple lesions (p = 0.032), presence of ulcerations (p ⟨ 0.001), age under 50 (p = 0.002). BCCs were more likely to be correctly diagnosed than SCC (p ⟨ 0.001). Cases with multiple BCCs were thinner compared to single-lesion excisions (p ⟨ 0.001). A tumor reduction was observed after the 2020 the SARS-CoV-2 (p = 0.023).

Conclusions

Differentiating NMSC can be challenging, but several trends have been observed which may aid in further improving the diagnosis rates especially for SCCs.

Abstract Image

查看原文本刊更多论文

非黑色素瘤皮肤癌的诊断挑战和影响因素：对基底细胞癌和鳞状细胞癌病例的回顾性分析

非黑色素瘤皮肤癌（NMSC）是全球最常见的皮肤肿瘤。基底细胞癌（BCC）和鳞状细胞癌（SCC）是这一群体中最常见的代表，在某些难以区分的肿瘤情况下，它们可能是诊断上的挑战。目的本研究的目的是确定影响NMSC诊断的因素及其影响。方法与结果采用单中心、描述性、回顾性研究，2016 - 2022年间678例患者共切除866个肿瘤。然后根据其组织学诊断和特征以及现有的临床资料对病例进行分析。在866例病例中，709例组织学诊断为BCC， 157例为SCC。bcc的临床准确性为95%，而SCCs的临床准确性为62%，两者在主治皮肤科医生之间差异很大。发现影响诊断的临床因素为：高龄（p⟨0.001）、事先活检（p = 0.009）和多次诊断或不确定性（p = 0.005）可预测SCC的最终诊断。预测bcc的因素有：多发病变（p = 0.032）、溃疡（p⟨0.001）、年龄小于50 （p = 0.002）。bcc比SCC更容易被正确诊断（p⟨0.001）。多发bcc的病例比单病灶切除的病例更薄（p⟨0.001）。2020年SARS-CoV-2感染后肿瘤减少（p = 0.023）。结论：鉴别NMSC可能具有挑战性，但已经观察到一些趋势，这些趋势可能有助于进一步提高诊断率，特别是对于SCCs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊