Sulfadiazine Detection in Milk Using F−-modified Ag-TpBD-COF as SERS Substrate

IF 3 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Analytical Methods Pub Date : 2025-07-13 DOI:10.1007/s12161-025-02860-5

Yunpeng Shang, Anqi Hu, Chaoqun Ma, Jiao Gu, Yamin Wu, Chun Zhu, Lei Li, Hui Gao, Taiqun Yang, Guoqing Chen

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引用次数: 0

Abstract

Sulfadiazine, an antibiotic belonging to the sulfonamide class, is commonly utilized in aquaculture and animal farming because of its affordability. However, the misuse of this antibiotic can lead to harmful health effects in humans, necessitating effective methods for detecting its residues in food products. Despite advancements in residue detection, challenges remain, particularly in dealing with interference from complex food matrices like milk. In this research, we synthesized F-modified Ag-TpBD-COF materials to serve as substrates for surface-enhanced Raman spectroscopy (SERS), aiming to detect sulfadiazine residues in milk. The Covalent organic frameworks (COF) materials, serving as ligands, effectively minimized interference, enhancing the method’s accuracy. The method demonstrated excellent sensitivity with a linear detection range of 1–50 μg/L and a limit of detection (LOD) was 0.69 μg/L. These findings highlight the potential of the novel Ag-TpBD-COF SERS substrate for high-sensitivity and reliable food safety monitoring.

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用F−修饰Ag-TpBD-COF作为SERS底物检测牛奶中的磺胺嘧啶

磺胺嘧啶是一种属于磺胺类的抗生素，由于其价格低廉，通常用于水产养殖和动物养殖。然而，这种抗生素的滥用会对人类健康造成有害影响，因此需要有效的方法来检测其在食品中的残留。尽管在残留物检测方面取得了进步，但挑战仍然存在，特别是在处理来自牛奶等复杂食物基质的干扰方面。在这项研究中，我们合成了f修饰的Ag-TpBD-COF材料，作为表面增强拉曼光谱（SERS）的底物，旨在检测牛奶中的磺胺嘧啶残留。共价有机框架（COF）材料作为配体，有效地减少了干扰，提高了方法的准确性。该方法灵敏度高，线性检测范围为1 ~ 50 μg/L，检出限为0.69 μg/L。这些发现突出了新型Ag-TpBD-COF SERS底物在高灵敏度和可靠的食品安全监测方面的潜力。

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来源期刊

Food Analytical Methods 农林科学-食品科技

CiteScore

6.00

自引率

3.40%

发文量

244

审稿时长

3.1 months

期刊介绍： Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.