Polydatin: A natural compound with multifaceted anticancer properties

IF 3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Traditional and Complementary Medicine Pub Date : 2025-09-01 DOI:10.1016/j.jtcme.2024.06.006

Khalid Imtiyaz, Mohsin Shafi, Khalid Umar Fakhri, Laraib Uroog, Bushra Zeya, Syed Tauqeer Anwer, M Moshahid Alam Rizvi

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Abstract

Cancer poses a significant global health challenge, contributing to substantial mortality rates and driving the urgent need for exploration into bioactive compounds with potent anticancer properties. Polydatin (PD), a stilbenoid compound abundant in various fruits and vegetables, has emerged as a promising candidate in cancer research. Renowned in traditional Chinese medicine for its multifaceted biological activities encompassing antioxidant, anti-inflammatory, anticancer, hepatoprotective, neuroprotective, and immunostimulatory effects, PD stands out as a versatile therapeutic agent. This review paper meticulously compiles the diverse anticancer attributes of polydatin across a spectrum of cancer types, elucidating its impact on pivotal cancer hallmarks such as proliferation, migration, metastasis, apoptosis, modulation of the tumour microenvironment, autophagy, and more. Furthermore, the review intricately explores the intricate pathways influenced by polydatin within cancer cells, unveiling its mechanisms of action and identifying potential therapeutic targets. By providing a comprehensive analysis of how polydatin affects various facets of cancer progression and addresses treatment resistance, this paper aims to enhance our understanding of its pivotal role in cancer therapy. Moreover, the synergistic potential of polydatin in combination with other drugs is investigated to underscore its amplified efficacy in combating cancer through innovative mechanism-based strategies. The synthesis of these insights underscores polydatin's significance as a valuable component in the advancement of novel approaches to cancer prevention and treatment.

Goals

This review aims to comprehensively compile and analyze the diverse anticancer attributes of polydatin (PD) across various cancer types, elucidating its impact on pivotal cancer hallmarks such as proliferation, migration, metastasis, apoptosis, and modulation of the tumour microenvironment. Additionally, it explores the intricate pathways influenced by polydatin within cancer cells, unveiling its mechanisms of action and identifying potential therapeutic targets. Moreover, the review investigates polydatin's potential synergistic effects with other anticancer drugs, while also examining its therapeutic and preventive effects against various cancers.

Methods

A systematic review of scientific literature, comprising research articles, clinical trials, and reviews, was conducted to analyze polydatin's anticancer properties. Reputable databases like PubMed, ScienceDirect, and Google Scholar were searched, and selected studies were critically evaluated to extract essential insights into polydatin's mechanisms of action and its interactions with other anticancer drugs, utilizing keywords targeting specific cancer types such as colorectal, oral, breast, and cervical cancer.

Findings

The review and additional online research on polydatin reveal that it exhibits multifaceted biological activities, including antioxidant, anti-inflammatory, and anticancer effects. Across various cancer types, polydatin demonstrates promising properties, impacting key cancer hallmarks such as proliferation and metastasis. These findings underscore polydatin's diverse therapeutic potential, particularly in cancer treatment, by targeting crucial pathways involved in cancer progression and offering insights into its mechanisms of action.

Results

Polydatin shows potential as a valuable component in cancer therapy, addressing various facets of cancer progression and treatment resistance.

Synergistic potential with other drugs suggests amplified efficacy in combating cancer through innovative mechanism-based strategies.

The review underscores the significance of polydatin in the advancement of novel approaches for cancer prevention and treatment.

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多甙：一种具有多方面抗癌特性的天然化合物

癌症是一项重大的全球健康挑战，导致大量死亡率，并迫切需要探索具有强效抗癌特性的生物活性化合物。多种水果和蔬菜中含有丰富的二苯乙烯类化合物聚乙二醇苷（polydatatin， PD），它已成为癌症研究中一个很有前途的候选物质。PD因其多方面的生物活性，包括抗氧化、抗炎、抗癌、保肝、保神经和免疫刺激作用而在传统中医中享有盛名，是一种多用途的治疗剂。这篇综述文章精心整理了多聚葡聚糖在多种癌症类型中的多种抗癌特性，阐明了其对关键癌症特征的影响，如增殖、迁移、转移、凋亡、肿瘤微环境的调节、自噬等。此外，本文还探讨了癌细胞内受多聚肽影响的复杂途径，揭示了其作用机制并确定了潜在的治疗靶点。通过全面分析多聚胆碱如何影响癌症进展的各个方面并解决治疗耐药性，本文旨在增强我们对其在癌症治疗中的关键作用的理解。此外，我们还研究了多聚丹素与其他药物联合的协同潜力，以强调其通过基于创新机制的策略在抗癌方面的放大功效。这些见解的综合强调了聚datatin作为癌症预防和治疗新方法的重要组成部分的重要性。本综述旨在全面整理和分析多聚葡聚糖（PD）在不同癌症类型中的多种抗癌特性，阐明其对肿瘤增殖、迁移、转移、凋亡和肿瘤微环境调节等关键癌症特征的影响。此外，它还探索了癌细胞内受多聚肽影响的复杂途径，揭示了其作用机制并确定了潜在的治疗靶点。此外，本文还探讨了多果苷与其他抗癌药物的潜在协同作用，以及对各种癌症的治疗和预防作用。方法系统回顾科学文献，包括研究文章、临床试验和综述，分析多柚皮苷的抗癌特性。我们检索了PubMed、ScienceDirect和谷歌Scholar等知名数据库，并对选定的研究进行了严格评估，以提取有关聚datatin作用机制及其与其他抗癌药物相互作用的重要见解，并利用针对特定癌症类型（如结肠直肠癌、口腔癌、乳腺癌和宫颈癌）的关键词。研究结果：该综述和对多聚丹素的其他在线研究表明，它具有多方面的生物活性，包括抗氧化、抗炎和抗癌作用。在各种类型的癌症中，聚胆碱显示出有希望的特性，影响关键的癌症特征，如增殖和转移。这些发现强调了聚datatin的多种治疗潜力，特别是在癌症治疗中，通过靶向癌症进展的关键途径并提供对其作用机制的见解。结果多聚氰胺在癌症治疗中显示出潜在的有价值的成分，可以解决癌症进展和治疗耐药的各个方面。与其他药物的协同作用潜力表明，通过创新的机制为基础的策略，增强了抗癌的功效。这篇综述强调了多聚胆碱在癌症预防和治疗新方法发展中的重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Traditional and Complementary Medicine Medicine-Complementary and Alternative Medicine

CiteScore

9.30

自引率

6.70%

发文量

审稿时长

66 days

期刊介绍： eJTCM is committed to publish research providing the biological and clinical grounds for using Traditional and Complementary Medical treatments as well as studies that demonstrate the pathophysiological and molecular/biochemical bases supporting the effectiveness of such treatments. Review articles are by invitation only. eJTCM is receiving an increasing amount of submission, and we need to adopt more stringent criteria to select the articles that can be considered for peer review. Note that eJTCM is striving to increase the quality and medical relevance of the publications.