Development of bioactive PLA nanofiber wound dressings with Hypericum perforatum and zeolite

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-08-29 DOI:10.1016/j.matlet.2025.139384

Seviye Nur Caliskan , Yara Farrah , Nazlican Demircan , Berke Veli Yilmaz , Yigit Furkan Alaca , Esra Pilavci , Zehra Kanli , Elif Kaya , Gulgun Tinaz , Canan Dogan , Oguzhan Gunduz

引用次数: 0

Abstract

This study presents the development of innovative wound dressings using Poly (Lactic Acid) (PLA) nanofibers functionalised with Hypericum perforatum (HP) extract and natural zeolite (ZEO). Nanofibers were fabricated via electrospinning and characterised. Results revealed that HP and ZEO significantly enhanced the thermal stability, mechanical strength, and biocompatibility of the nanofibers. When in vitro release of HP was analyzed, it was found to be finally released within 18 days. HP and ZEO together were increased the mechanical strength to the value of 1.84 ± 0.53 MPa. This study highlights the synergy of natural bioactive compounds and sustainable materials in creating advanced wound care solutions.

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穿孔连翘与沸石复合生物活性聚乳酸纳米纤维创面敷料的研制

本研究介绍了用贯叶连翘（HP）提取物和天然沸石（ZEO）功能化的聚乳酸（PLA）纳米纤维开发的创新伤口敷料。采用静电纺丝法制备了纳米纤维，并对其进行了表征。结果表明，HP和ZEO显著提高了纳米纤维的热稳定性、机械强度和生物相容性。当分析HP的体外释放时，发现它在18天内最终释放。HP和ZEO共同将机械强度提高到1.84±0.53 MPa。这项研究强调了天然生物活性化合物和可持续材料在创造先进伤口护理解决方案中的协同作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive