An Integrated Immuno-Reward Model of Adolescent Depression: Theory, Evidence, and Implications

IF 5.8 1区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY
Lauren B. Alloy, Robin Nusslock
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引用次数: 0

Abstract

Adolescence is an “age of risk” for the emergence of depression. Despite its prevalence and public-health significance, there are major unanswered questions regarding the mechanisms contributing to depression’s etiology and surge in adolescence. Separate lines of research have investigated the roles of inflammation and low reward responsiveness in depression, and recent evidence suggests bidirectional associations between inflammation and reward responsiveness. In this article, we review this evidence, present an integrated immuno-reward model of adolescent depression (specifically, motivational and somatic symptoms of depression), and discuss the role of stress and early adversity in amplifying immune-reward interactions. We end with implications of the immuno-reward model for future research, early identification of at-risk adolescents, intervention, and public-health policy.
青少年抑郁的综合免疫-奖励模型:理论、证据和意义
青春期是出现抑郁症的“风险年龄”。尽管它的普遍性和公共卫生意义,关于抑郁症的病因和青春期激增的机制,仍有一些主要的未解之谜。不同的研究已经调查了炎症和低奖励反应在抑郁症中的作用,最近的证据表明炎症和奖励反应之间存在双向关联。在本文中,我们回顾了这些证据,提出了青少年抑郁症的综合免疫-奖励模型(特别是抑郁症的动机和躯体症状),并讨论了压力和早期逆境在放大免疫-奖励相互作用中的作用。最后,我们讨论了免疫奖励模型对未来研究、早期识别高危青少年、干预和公共卫生政策的影响。
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来源期刊
Current Directions in Psychological Science
Current Directions in Psychological Science PSYCHOLOGY, MULTIDISCIPLINARY-
CiteScore
13.00
自引率
1.40%
发文量
61
期刊介绍: Current Directions in Psychological Science publishes reviews by leading experts covering all of scientific psychology and its applications. Each issue of Current Directions features a diverse mix of reports on various topics such as language, memory and cognition, development, the neural basis of behavior and emotions, various aspects of psychopathology, and theory of mind. These articles allow readers to stay apprised of important developments across subfields beyond their areas of expertise and bodies of research they might not otherwise be aware of. The articles in Current Directions are also written to be accessible to non-experts, making them ideally suited for use in the classroom as teaching supplements.
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