Oxidase subunit unexpectedly prevents oxidation of calcium pump and cardiac dysfunction

Abstract

This study identifies a non-canonical role of p22phox (a subunit of NADPH oxidases) in cardiac protection: by directly binding the sarcoplasmic reticulum calcium pump SERCA2a and preventing its oxidation, p22phox preserves SERCA2a stability and maintains calcium cycling and cardiac function under stress. This mechanism is crucial for modulating SERCA2a levels in heart failure.