Gastrointestinal microbiota in treatment of gastric precancerous lesions and gastric cancer by Western and traditional Chinese medicine.

IF 3.2 Q3 ONCOLOGY
Ting-Lan Cao, Hui-Zhong Jiang
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引用次数: 0

Abstract

Gastric precancerous lesions (GPL) represent a crucial stage in the complex process of gastric carcinogenesis that leads to gastric cancer (GC), one of the most prevalent cancers and a major source of cancer mortality worldwide. Many studies have identified the gastrointestinal microbiota, or gut microbiota, as an important contributor to both the pathogenesis and treatment of GPL and GC, thus understanding its role in this transition is crucial. The purpose of this literature review is to introduce the current landscape of microbiota research associated with GPL and GC, with an emphasis on Helicobacter pylori (H. pylori) driven microbial dysbiosis and its modulation through Western medicine and traditional Chinese medicine (TCM) approaches. By elucidating the underlying mechanisms of H. pylori colonization, patterns, and interactions among microbiota, as well as the influence of microbial metabolites, this review highlights crucial driving factors of gastric carcinogenesis. The role of microbiota in conventional interventions, including H. pylori eradication, immunotherapy, as well as TCM herbal decoctions, is also discussed to provide a detailed understanding of the complex interactions between therapy and microbiota and how it could be potentially targeted for effective management of GPL and GC. Ultimately, microbiota-targeting therapeutics may represent a new path toward early detection, targeted treatment, improved prognosis, and potentially reduced incidence of GPL and GC.

Abstract Image

Abstract Image

胃肠道微生物群在中西医结合治疗胃癌前病变和胃癌中的作用。
胃癌前病变(GPL)是导致胃癌(GC)的复杂胃癌发生过程的关键阶段,胃癌是世界上最常见的癌症之一,也是癌症死亡率的主要来源。许多研究已经确定胃肠道微生物群或肠道微生物群是GPL和GC发病和治疗的重要因素,因此了解其在这一转变中的作用至关重要。本文献综述的目的是介绍与GPL和GC相关的微生物群研究的现状,重点是幽门螺杆菌(H. pylori)驱动的微生物生态失调及其通过西医和中医(TCM)方法的调节。通过阐明幽门螺杆菌定植的潜在机制,模式,微生物群之间的相互作用,以及微生物代谢物的影响,本综述强调了胃癌发生的关键驱动因素。本文还讨论了微生物群在常规干预措施中的作用,包括幽门螺杆菌根除、免疫治疗以及中药煎剂,以详细了解治疗与微生物群之间的复杂相互作用,以及它如何可能成为有效管理GPL和GC的潜在目标。最终,微生物群靶向治疗可能是早期发现、靶向治疗、改善预后和潜在降低GPL和GC发病率的新途径。
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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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