Current advances in neuroendocrine neoplasms of the colon and rectum.

IF 3.2 Q3 ONCOLOGY
Yun-Bin Ma, Zhi-Jie Wang
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引用次数: 0

Abstract

Compared with colorectal adenocarcinoma, neuroendocrine neoplasms (NENs), which affect the colon and rectum, are uncommon tumor conditions that have received relatively limited attention in basic research. Furthermore, the scarcity of these NENs has hindered extensive clinical investigations, thereby leading to a dearth of robust evidence for guiding clinical practice and impeding the establishment of standardized approaches for diagnosis and treatment. However, with the increasing awareness of population screening, as well as the increasing popularity of colonoscopy screening programs, the incidence of colorectal NENs has gradually increased. Moreover, some high-grade NENs are highly malignant and invasive, thereby leading to poor treatment outcomes and prognoses. These challenges have elicited increased attention from clinical physicians, thus prompting researchers to explore relevant studies using limited specimens and clinical data. This scenario has resulted in preliminary findings that provide evidence for addressing diagnostic and therapeutic challenges associated with NENs of the colon and rectum. In this article, we review recent literature reports and summarize the advances regarding the diagnosis and treatment of colorectal NENs.

结肠和直肠神经内分泌肿瘤的最新进展。
与结直肠腺癌相比,影响结肠和直肠的神经内分泌肿瘤(NENs)是一种罕见的肿瘤,在基础研究中受到的关注相对较少。此外,这些nen的缺乏阻碍了广泛的临床调查,从而导致缺乏指导临床实践的有力证据,阻碍了标准化诊断和治疗方法的建立。然而,随着人群筛查意识的提高,以及结肠镜筛查项目的日益普及,结直肠NENs的发病率逐渐增加。此外,一些高级别NENs是高度恶性和侵袭性的,从而导致较差的治疗结果和预后。这些挑战引起了临床医生越来越多的关注,从而促使研究人员利用有限的标本和临床数据探索相关研究。这种情况导致的初步发现为解决与结肠和直肠NENs相关的诊断和治疗挑战提供了证据。在这篇文章中,我们回顾了最近的文献报道,并总结了有关诊断和治疗结直肠neens的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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