{"title":"Role of physical activity in cancer prevention: An update.","authors":"Deepak Dhamnetiya, Aishwarya Sharma","doi":"10.5306/wjco.v16.i8.107765","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer prevention <i>via</i> regular physical activity has been studied across the world. This minireview aimed to present the latest updates in research in the context of the role of physical activity in the cancer prevention. The various mechanisms at the molecular level were studied in depth. The essential processes at play involving hormonal balance, weight reduction, adiposity, inflammation, immunity, sunlight exposure and vitamin D levels and insulin resistance were critically analyzed here. The dose response of exercise with respect to cancer prevention was appraised. Strong evidence supports an inverse relationship between physical activity and cancer risk, particularly for breast, liver, lung and colorectal cancers. There is limited evidence for hematologic, head and neck, ovarian, pancreas, prostate, brain, thyroid and rectal cancer. Prehabilitation plays a key role in tertiary prevention of cancer and patient symptom alleviation. The role of physical activity was studied under the entire cancer continuum, from primary to tertiary prevention. The minireview highlights the need for interventional trials involving holistic methods combing modern and traditional medicine/therapies in cancer prevention.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 8","pages":"107765"},"PeriodicalIF":3.2000,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400211/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5306/wjco.v16.i8.107765","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer prevention via regular physical activity has been studied across the world. This minireview aimed to present the latest updates in research in the context of the role of physical activity in the cancer prevention. The various mechanisms at the molecular level were studied in depth. The essential processes at play involving hormonal balance, weight reduction, adiposity, inflammation, immunity, sunlight exposure and vitamin D levels and insulin resistance were critically analyzed here. The dose response of exercise with respect to cancer prevention was appraised. Strong evidence supports an inverse relationship between physical activity and cancer risk, particularly for breast, liver, lung and colorectal cancers. There is limited evidence for hematologic, head and neck, ovarian, pancreas, prostate, brain, thyroid and rectal cancer. Prehabilitation plays a key role in tertiary prevention of cancer and patient symptom alleviation. The role of physical activity was studied under the entire cancer continuum, from primary to tertiary prevention. The minireview highlights the need for interventional trials involving holistic methods combing modern and traditional medicine/therapies in cancer prevention.
期刊介绍：
The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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