Exploring salivary metabolites as biomarkers in chronic craniofacial and orofacial pain: a metabolomic analysis.

IF 3.3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolomics Pub Date : 2025-09-04 DOI:10.1007/s11306-025-02336-x

Weronika Jasinska, Yonatan Birenzweig, Yair Sharav, Doron J Aframian, Yariv Brotman, Yaron Haviv

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引用次数: 0

Abstract

Introduction: Chronic facial pain (CFP) includes a range of conditions such as musculoskeletal, neurovascular, and neuropathic disorders affecting the facial and jaw regions, often causing significant distress to patients.

Objectives: This study aims to investigate the metabolomic profile of patients with CFP, focusing on salivary metabolites as potential biomarkers for pain diagnosis and management.

Methods: Metabolomics investigation was performed using combined liquid chromatography with mass spectrometry (UPLC-MS) for metabolic profiling.

Results: A comprehensive analysis was conducted, utilizing both untargeted and targeted metabolomics to examine 28 metabolites previously associated with pain conditions. The results revealed significant differences in 18 metabolites between the CFP group and a control group, with seven metabolites consistently showing elevated levels regardless of gender: DL-Isoleucine, DL-Glutamine, DL-Citrulline, D-(+)-Pyroglutamic acid, DL-Tryptophan, DL-Phenylalanine, and Spermidine.

Conclusions: The findings suggest a potential link between specific salivary metabolites and CFP, highlighting the complexity of pain mechanisms. Further research is needed to understand the causality and implications of these metabolic changes, which could lead to more targeted and personalized approaches in managing pain.

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探索唾液代谢物作为慢性颅面和口面疼痛的生物标志物：代谢组学分析。

慢性面部疼痛（CFP）包括一系列疾病，如影响面部和颌骨的肌肉骨骼、神经血管和神经性疾病，通常会给患者带来严重的痛苦。目的：本研究旨在研究CFP患者的代谢组学特征，重点研究唾液代谢物作为疼痛诊断和治疗的潜在生物标志物。方法：采用液相色谱-质谱联用（UPLC-MS）进行代谢组学研究。结果：进行了全面的分析，利用非靶向和靶向代谢组学检查了先前与疼痛状况相关的28种代谢物。结果显示，CFP组与对照组之间的18种代谢物存在显著差异，其中7种代谢物水平持续升高，与性别无关：dl -异亮氨酸、dl -谷氨酰胺、dl -瓜氨酸、D-(+)-焦谷氨酸、dl -色氨酸、dl -苯丙氨酸和亚精胺。结论：研究结果表明特定唾液代谢物与CFP之间存在潜在联系，强调了疼痛机制的复杂性。需要进一步的研究来了解这些代谢变化的因果关系和影响，这可能会导致更有针对性和个性化的方法来管理疼痛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolomics 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.80%

发文量

审稿时长

2 months

期刊介绍： Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.