Improvement of spermogenesis impairment induced by high-fat diet in obese mice through pyrroloquinoline quinone regulation of glycolysis pathway.

Abstract

This study employed an obese mouse model to investigate the effects of pyrroloquinoline quinone (PQQ) intervention on reproductive physiology and glycolytic pathways. Our findings demonstrate that PQQ markedly enhanced glycolytic activity in obese mice, promoting glucose breakdown and metabolism to improve energy supply efficiency. These metabolic improvements correlated with significant support for reproductive system functionality. Mechanistic analyses revealed PQQ's potential to augment mitochondrial respiration, ameliorate mitochondrial dysfunction, and counteract obesity-associated inflammation, thereby preserving the balance between fatty acid degradation and integrated glycolysis-cholesterol metabolism. Collectively, this work provides novel insights into PQQ's molecular mechanisms for promoting glycolysis and ameliorating infertility in obese males.