Parmanand Malvi, Patrick Ball, Romi Gupta, Narendra Wajapeyee
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引用次数: 0
Abstract
RNA molecules are subject to extensive post-transcriptional modifications that fine-tune their stability, localization, and function. Among the more than 100 known RNA modifications, N6-methyladenosine (m6A) is the most abundant internal mark on eukaryotic messenger RNAs. This dynamic modification is installed by methyltransferases ("writers"), removed by demethylases ("erasers"), and interpreted by RNA-binding proteins ("readers") to modulate gene expression. In this review, we examine the mechanisms governing m6A deposition and its broad impact on mRNA fate. We then focus on the emerging roles of m6A in shaping antitumor immune responses and discuss how targeting m6A-regulated pathways can enhance the efficacy of existing immunotherapies. Finally, we highlight recent advances and ongoing challenges in the development of drugs that target key regulators of m6A RNA modifications.
期刊介绍：
The Journal for ImmunoTherapy of Cancer (JITC) is a peer-reviewed publication that promotes scientific exchange and deepens knowledge in the constantly evolving fields of tumor immunology and cancer immunotherapy. With an open access format, JITC encourages widespread access to its findings. The journal covers a wide range of topics, spanning from basic science to translational and clinical research. Key areas of interest include tumor-host interactions, the intricate tumor microenvironment, animal models, the identification of predictive and prognostic immune biomarkers, groundbreaking pharmaceutical and cellular therapies, innovative vaccines, combination immune-based treatments, and the study of immune-related toxicity.
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