Does the addition of fentanyl premedication impact brown fat uptake in children undergoing a warming protocol for FDG PET?

IF 2.3 3区医学 Q2 PEDIATRICS

Pediatric Radiology Pub Date : 2025-09-04 DOI:10.1007/s00247-025-06381-5

Mariama Lukulay, Pradipta Debnath, Christopher G Anton, Yinan Li, Adam F Prasanphanich, Susan E Sharp, Bin Zhang, Andrew T Trout, Cara E Morin

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引用次数: 0

Abstract

Background: Fentanyl is used in some pediatric practices with a goal of suppressing 18F-fluorodeoxyglucose (18F-FDG) uptake in brown fat.

Objective: The purpose of this study was to examine the frequency, intensity, and distribution of brown fat uptake in warmed children undergoing 18F-FDG PET/CT with and without premedication with fentanyl. MATERIALS AND METHODS: This retrospective study included children (< 18 years old) who underwent 18F-FDG-PET from 2014 to 2024 at a center that routinely warms patients and uses intravenous fentanyl for brown fat suppression for most patients. Three radiologists assessed the presence, intensity, and location of brown fat uptake. Chi-square test and two-sample t-test were used to compare the demographics and brown fat uptake between premedication and non-premedication groups.

Results: Among 873 18F-FDG-PETs, 595 (68%) were performed with fentanyl premedication and warming and 278 (32%) were conducted with warming alone. Brown fat uptake was observed in 46 (5.3%) FDG-PETs, 32/595 (5.4%) in the premedicated group and 14/278 (5.0%) in the non-premedicated group (P = 0.83). No differences were found in brown fat intensity or location based on premedication status. Age (14.5 vs. 8.5; P < 0.001) and BMI (20.1 vs. 17.7; P < 0.001) were significantly associated with brown fat uptake.

Conclusion: Fentanyl premedication does not significantly affect brown fat uptake frequency, intensity, or location in warmed children undergoing 18F-FDG-PET.

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在接受FDG PET加热治疗方案的儿童中，药物前添加芬太尼会影响棕色脂肪的摄取吗？

背景：芬太尼用于一些儿科实践，目的是抑制棕色脂肪中18f -氟脱氧葡萄糖（18F-FDG）的摄取。目的：本研究的目的是检查发热儿童在接受18F-FDG PET/CT检查时，有无芬太尼预用药时棕色脂肪摄取的频率、强度和分布。材料与方法：本回顾性研究纳入儿童(结果：873例18f - fdg - pet中，595例（68%）采用芬太尼预用药加温疗，278例（32%）采用单纯温疗。fdg - pet有46只（5.3%）摄取棕色脂肪，预用药组有32/595只（5.4%），未预用药组有14/278只（5.0%）（P = 0.83）。未发现基于用药前状态的棕色脂肪强度或位置的差异。结论：芬太尼预用药对接受18F-FDG-PET治疗的温暖儿童棕色脂肪摄取频率、强度或位置无显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Radiology 医学-核医学

CiteScore

4.40

自引率

17.40%

发文量

300

审稿时长

3-6 weeks

期刊介绍： Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.