Severe Dietary Zinc Deficiency Does Not Significantly Alter Energy Balance in Adult Mice.

IF 2.4 Q3 NUTRITION & DIETETICS
Journal of Nutrition and Metabolism Pub Date : 2025-08-25 eCollection Date: 2025-01-01 DOI:10.1155/jnme/6911386
Caitlin C Murdoch, Andy Weiss, Kyle T Enriquez, Kacie A Traina, Sydney L Drury, Nathan C Winn, Louise L Lantier, Eric P Skaar
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Abstract

Zinc (Zn) is an essential dietary nutrient metal that functions as a cofactor for numerous enzymes involved in diverse cellular processes, including energy metabolism. In humans, Zn deficiency afflicts an estimated one-third of the global population and is a prominent risk factor for numerous diseases, including the development of obesity and diabetes. It is known that severe Zn deficiency leads to impaired growth and development in animals, suggesting that this dietary micronutrient is required for the maintenance of organismal energy balance. However, the impact of Zn restriction on energy balance, specifically energy intake versus expenditure, remains incompletely described in existing murine models of Zn deficiency. Here, we characterized the impact of a prolonged Zn-restricted diet on animal growth, energy balance, and glucose metabolism using metabolic cage analysis and oral glucose tolerance tests in adult mice. While we demonstrated dietary Zn-dependent reductions in body weight with concomitant decreases in energy expenditure and energy intake, we found no significant alterations in energy balance. Furthermore, we observed modest sex-dependent impacts on glucose tolerance. Collectively, these data highlight that prolonged, severe Zn restriction in adult mice does not elicit significant changes in metabolic parameters such as overall energy balance and glucose clearance. These findings indicate that other factors lead to the changes in body weight and composition in Zn-deficient mice.

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严重的膳食锌缺乏不会显著改变成年小鼠的能量平衡。
锌(Zn)是一种必需的膳食营养金属,作为多种酶的辅助因子参与多种细胞过程,包括能量代谢。在人类中,锌缺乏症折磨着全球约三分之一的人口,是许多疾病的一个突出的危险因素,包括肥胖和糖尿病的发展。众所周知,严重的锌缺乏会导致动物生长发育受损,这表明这种膳食微量营养素是维持机体能量平衡所必需的。然而,锌限制对能量平衡的影响,特别是能量摄入与消耗的影响,在现有的锌缺乏小鼠模型中仍然没有得到完全的描述。在这里,我们通过代谢笼分析和成年小鼠口服葡萄糖耐量试验,描述了长期限锌饮食对动物生长、能量平衡和葡萄糖代谢的影响。虽然我们证明了饮食中锌依赖的体重减少伴随着能量消耗和能量摄入的减少,但我们发现能量平衡没有显著改变。此外,我们观察到葡萄糖耐量有适度的性别依赖性影响。总的来说,这些数据强调了成年小鼠长期严格的锌限制不会引起代谢参数(如总能量平衡和葡萄糖清除率)的显着变化。这些发现表明,其他因素导致了锌缺乏小鼠体重和成分的变化。
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来源期刊
Journal of Nutrition and Metabolism
Journal of Nutrition and Metabolism NUTRITION & DIETETICS-
CiteScore
5.40
自引率
0.00%
发文量
49
审稿时长
17 weeks
期刊介绍: Journal of Nutrition and Metabolism is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering the broad and multidisciplinary field of human nutrition and metabolism. The journal welcomes submissions on studies related to obesity, diabetes, metabolic syndrome, molecular and cellular biology of nutrients, foods and dietary supplements, as well as macro- and micronutrients including vitamins and minerals.
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