Strengthening benefits of panthenol for hair: Mechanistic evidence from advanced spectroscopic techniques.

IF 2.5 4区 医学 Q2 DERMATOLOGY
Jennifer M Marsh, Scott Cron, Tian Chen, Allison Talley, Shane Whitaker, Haibo Jiang, Kai Xue
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Abstract

Objective: Small molecules, like panthenol have been shown to penetrate hair. However, their interactions with the protein structures of hair have not been well studied. In this study, the penetration of panthenol into protein structures of hair was confirmed, and NMR methods were utilized to understand the protein-panthenol interaction. This interaction is likely the source of the tensile strength benefits measured with panthenol for hair.

Methods: Cross-sections of hair treated with deuterium-labelled panthenol were studied using NanoSIMS to visualize the location of panthenol within hair. Solid-state NMR (both 1H-13C and 1H-2H) was employed to measure panthenol interactions inside hair using deuterium-labelled panthenol. Stress/strain curves-where stress is defined as average force per unit area-were measured for hair treated with and without panthenol to generate tensile strength data.

Results: Penetration of panthenol into hair was demonstrated, with images indicating specific penetration into cortical protein regions. NMR results from various experiments provided evidence of direct interaction between the N-H of panthenol and protein aromatic side chains. A 'shared' proton was identified between panthenol and hair proteins, indicating spatial proximity and interaction. Break stress and elastic modulus of hair treated with panthenol were higher than those of control hair, suggesting that bonds-likely hydrogen bonds-were formed between panthenol and hair.

Conclusion: Panthenol can deliver tensile strength benefits to hair. This benefit is proposed to result from hydrogen bonds formed between panthenol and hair proteins.

泛醇对头发的强化益处:来自先进光谱技术的机理证据。
目的:像泛醇这样的小分子已经被证明可以穿透头发。然而,它们与头发蛋白质结构的相互作用还没有得到很好的研究。在本研究中,证实了泛醇对头发蛋白质结构的渗透,并利用NMR方法了解了蛋白质-泛醇的相互作用。这种相互作用很可能是泛醇对头发抗拉强度有益的来源。方法:利用NanoSIMS对经氘标记的泛醇处理过的头发的横截面进行研究,以显示泛醇在头发中的位置。采用固体核磁共振(1H-13C和1H-2H)测量头发内氘标记的泛醇相互作用。应力/应变曲线——其中应力被定义为单位面积的平均力——测量了用和不用泛醇处理的头发,以产生抗拉强度数据。结果:证实了泛醇对头发的渗透,图像显示了对皮层蛋白质区域的特异性渗透。各种实验的核磁共振结果提供了泛醇的N-H与蛋白质芳香侧链之间直接相互作用的证据。在泛醇和毛发蛋白之间发现了一个“共享”质子,表明空间接近和相互作用。用泛醇处理过的头发的断裂应力和弹性模量比对照组的头发要高,这表明泛醇和头发之间形成了键——很可能是氢键。结论:泛醇可以提高头发的抗拉强度。这种益处被认为是由于泛醇和头发蛋白之间形成的氢键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
73
期刊介绍: The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.
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