Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-03 DOI:10.1186/s40001-025-03018-z

Fateme Moradi Moraddahande, Seyed Mahdi Emami Meybodi, Maryam Matin, Nafiseh Soleimani, Navid Ghasemzadeh, Ali Dehghani Firoozabadi

{"title":"Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.","authors":"Fateme Moradi Moraddahande, Seyed Mahdi Emami Meybodi, Maryam Matin, Nafiseh Soleimani, Navid Ghasemzadeh, Ali Dehghani Firoozabadi","doi":"10.1186/s40001-025-03018-z","DOIUrl":null,"url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) and, consequently, heart failure are life-threatening diseases, and they should be considered a worldwide health primacy. Conventional medical treatments have been unable to tackle the burden of disease thoroughly, and the limited availability of organ donors continues to pose a significant hurdle. This pressing need has prompted researchers to explore innovative regenerative techniques and expedite their progression into clinical trials, instilling fresh hope in patients who do not respond adequately to traditional therapies. Cardiac regeneration is an extensive approach that strives to repair irreversibly damaged heart tissue through groundbreaking scientific advancements, encompassing stem cells, tissue engineering, and cell-free therapies, collectively known as cardiovascular regenerative medicine (CaVaReM). The primary vision for CaVaReM is to develop regenerative-based therapies that can effectively cure cardiovascular disorders. This innovative field focuses on repairing and restoring damaged heart tissue, improving cardiac function, and ultimately enhancing the quality of life (QOL) in patients suffering from heart diseases. This review categorized cardiac regenerative therapies' present status, future opportunities, and challenges.</p>","PeriodicalId":11949,"journal":{"name":"European Journal of Medical Research","volume":"30 1","pages":"837"},"PeriodicalIF":3.4000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406451/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Medical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40001-025-03018-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Cardiovascular diseases (CVDs) and, consequently, heart failure are life-threatening diseases, and they should be considered a worldwide health primacy. Conventional medical treatments have been unable to tackle the burden of disease thoroughly, and the limited availability of organ donors continues to pose a significant hurdle. This pressing need has prompted researchers to explore innovative regenerative techniques and expedite their progression into clinical trials, instilling fresh hope in patients who do not respond adequately to traditional therapies. Cardiac regeneration is an extensive approach that strives to repair irreversibly damaged heart tissue through groundbreaking scientific advancements, encompassing stem cells, tissue engineering, and cell-free therapies, collectively known as cardiovascular regenerative medicine (CaVaReM). The primary vision for CaVaReM is to develop regenerative-based therapies that can effectively cure cardiovascular disorders. This innovative field focuses on repairing and restoring damaged heart tissue, improving cardiac function, and ultimately enhancing the quality of life (QOL) in patients suffering from heart diseases. This review categorized cardiac regenerative therapies' present status, future opportunities, and challenges.

Abstract Image

查看原文本刊更多论文

干细胞治疗在心血管再生医学（CaVaReM）中的现状和新前景。

心血管疾病（cvd）以及因此导致的心力衰竭是危及生命的疾病，它们应被视为世界范围内的首要健康问题。传统的医学治疗无法彻底解决疾病的负担，而器官捐献者的有限性继续构成重大障碍。这种迫切的需求促使研究人员探索创新的再生技术，并加快其进入临床试验的进程，为那些对传统疗法没有充分反应的患者注入新的希望。心脏再生是一种广泛的方法，通过突破性的科学进步，包括干细胞、组织工程和无细胞疗法，努力修复不可逆损伤的心脏组织，统称为心血管再生医学（CaVaReM）。CaVaReM的主要目标是开发能够有效治愈心血管疾病的再生疗法。这一创新领域专注于修复和恢复受损的心脏组织，改善心脏功能，最终提高心脏病患者的生活质量（QOL）。本文综述了心脏再生疗法的现状、未来的机遇和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.