Case report: atypical anti-SAE1 autoantibody manifestation with splinter hemorrhages as onset, and related to urothelial cancer.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2025-08-01 DOI:10.26355/eurrev_202508_37360

A Biglia, M C Sacchi, F Maggiore, V Morandi, E Cammarata, M M Ciriello, M R Pellico, L Agatea, C Pelazza, A Roveta, L M Castello

{"title":"Case report: atypical anti-SAE1 autoantibody manifestation with splinter hemorrhages as onset, and related to urothelial cancer.","authors":"A Biglia, M C Sacchi, F Maggiore, V Morandi, E Cammarata, M M Ciriello, M R Pellico, L Agatea, C Pelazza, A Roveta, L M Castello","doi":"10.26355/eurrev_202508_37360","DOIUrl":null,"url":null,"abstract":"BACKGROUND: Subungual splinter hemorrhages may represent an expression of infective endocarditis as well as autoimmune diseases or neoplasms. Anti-SAE1 autoantibody is directed against a small ubiquitin-like modifier-activating enzyme that plays a role in regulating transcription, cell cycle, and apoptosis. It is specific for dermatomyositis with skin rash and mild muscle involvement, and it can be associated with cancer. CASE REPORT: We describe the case of a patient who developed subungual splinter hemorrhages and acrocyanosis. Infections were excluded, and autoimmunity resulted in anti-SAE1 autoantibodies. A cancer screening found a high-grade urothelial carcinoma. The splinter hemorrhages disappeared after the carcinoma enucleation. CONCLUSIONS: Our case describes an atypical onset of anti-SAE1 dermatomyositis with splinter hemorrhages, potentially linked to urothelial cancer. This highlights the importance of comprehensive cancer screening in patients with unusual dermatomyositis presentations.Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-rev.jpg.","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 8","pages":"398-403"},"PeriodicalIF":3.3000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European review for medical and pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26355/eurrev_202508_37360","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

BACKGROUND: Subungual splinter hemorrhages may represent an expression of infective endocarditis as well as autoimmune diseases or neoplasms. Anti-SAE1 autoantibody is directed against a small ubiquitin-like modifier-activating enzyme that plays a role in regulating transcription, cell cycle, and apoptosis. It is specific for dermatomyositis with skin rash and mild muscle involvement, and it can be associated with cancer. CASE REPORT: We describe the case of a patient who developed subungual splinter hemorrhages and acrocyanosis. Infections were excluded, and autoimmunity resulted in anti-SAE1 autoantibodies. A cancer screening found a high-grade urothelial carcinoma. The splinter hemorrhages disappeared after the carcinoma enucleation. CONCLUSIONS: Our case describes an atypical onset of anti-SAE1 dermatomyositis with splinter hemorrhages, potentially linked to urothelial cancer. This highlights the importance of comprehensive cancer screening in patients with unusual dermatomyositis presentations.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-rev.jpg.

查看原文本刊更多论文

病例报告：不典型抗sae1自身抗体表现，以裂状出血为起病，与尿路上皮癌有关。

背景：趾下裂出血可能是感染性心内膜炎以及自身免疫性疾病或肿瘤的一种表现。抗sae1自身抗体是针对一个小的泛素样修饰激活酶，在调节转录、细胞周期和凋亡中起作用。它是皮肌炎特有的皮疹和轻度肌肉受累，它可以与癌症有关。病例报告：我们描述了一个病例的病人谁发展的脚趾骨下裂出血和肢绀。排除感染，自身免疫导致抗sae1自身抗体。癌症筛查发现高级别尿路上皮癌。癌去核后碎片性出血消失。结论：我们的病例描述了一个非典型的抗sae1皮肌炎伴裂状出血，可能与尿路上皮癌有关。这突出了在有不寻常皮肌炎表现的患者中进行全面癌症筛查的重要性。图形摘要：https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-rev.jpg。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)