Multiomics approach to evaluating personalized biomarkers of allergen immunotherapy

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology Pub Date : 2025-09-01 DOI:10.1016/j.jaci.2025.06.036

Mohamed H. Shamji PhD , William T. Fulton MSc , Ibrahim Animashaun MD , Elizabeth Palmer PhD , Katja Baerenfaller PhD , Milena Sokolowska MD, PhD , Domingo Barber MD, PhD , Michelle Huffaker MD , Carolyn Baloh MD , Oliver Pfaar MD, PhD , Markus Ollert MD, PhD , Ludger Klimek MD, PhD , Ronald L. Rabin MD , Anubha Tripathi MD , Alkis Togias MD , Stefan Vieths PhD , Wayne G. Shreffler MD, PhD , Janice A. Layhadi PhD

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引用次数: 0

Abstract

Recent advancements in genomics and “omic” technologies have ushered in a transformative era referred to as personalized or precision medicine. This innovative approach considers the unique genetic profiles of individuals, along with a range of variability factors, to devise tailored disease treatments and prevention strategies that cater to the distinct needs of each patient. Although the terms personalized medicine and precision medicine are frequently utilized interchangeably, it is essential to delineate the subtle distinctions between them. Personalized medicine concentrates on bespoke treatments and prevention strategies that are meticulously tailored for each individual. Conversely, precision medicine utilizes advanced gene sequencing and comprehensive data analytics to formulate specific treatments and prevention strategies for defined groups of individuals based on genetic, environmental, and lifestyle factors rather than focusing exclusively on individual patients. Therefore, precision medicine constitutes an extension of traditional personalized care, improving the accuracy of diagnosis, prognosis, and therapy estimations for each patient through the application of sophisticated molecular diagnostics and advanced imaging techniques enabled by recent technological innovations. The shift from personalized to precision medicine has gained considerable traction, particularly in the wake of the 2015 US Precision Medicine Initiative, which has further stimulated advancements in this domain. This review will explore multiomics approaches that have facilitated the evaluation of personalized biomarkers associated with allergen immunotherapy, particularly in the treatment of allergic diseases. By leveraging these innovative methodologies, we aspire to cultivate more effective and individualized patient care, ultimately enhancing health outcomes for individuals with allergies.

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多组学方法评估过敏原免疫治疗的个性化生物标志物

基因组学和“基因组学”技术的最新进展开创了一个被称为个性化或精准医疗的变革时代。这种创新的方法考虑了个体独特的遗传特征，以及一系列可变性因素，以设计量身定制的疾病治疗和预防策略，以满足每位患者的独特需求。虽然个性化医疗和精准医疗这两个术语经常互换使用，但有必要描述它们之间的细微区别。个性化医疗侧重于为每个人精心定制的定制治疗和预防策略。相反，精准医疗利用先进的基因测序和全面的数据分析，根据遗传、环境和生活方式等因素，为特定人群制定具体的治疗和预防策略，而不是只关注个别患者。因此，精准医疗是传统个性化护理的延伸，通过应用复杂的分子诊断和最新技术创新的先进成像技术，提高了每位患者的诊断、预后和治疗评估的准确性。从个性化到精准医疗的转变已经获得了相当大的牵引力，特别是在2015年美国精准医疗倡议之后，这进一步刺激了这一领域的进步。本综述将探讨多组学方法，这些方法促进了与过敏原免疫治疗相关的个性化生物标志物的评估，特别是在过敏性疾病的治疗中。通过利用这些创新的方法，我们渴望培养更有效和个性化的患者护理，最终提高过敏患者的健康结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Allergy and Clinical Immunology 医学-过敏

CiteScore

25.90

自引率

7.70%

发文量

1302

审稿时长

38 days

期刊介绍： The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.