AgSCF3-mediated direct Trifluoromethylthiolation of alkynyl iodides for aryl and alkyl ethynyl trifluoromethyl Sulfides

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-09-01 DOI:10.1016/j.tetlet.2025.155816

Jianquan Hong, Qiang Wang, Chunxiang Li, Shengying Gu, Jie Wang, Xifei Chen, Chongbin Wei, Xinxin Gong, Wenqi Li, Changge Zheng

引用次数: 0

Abstract

A practical synthetic method for the ethynyl trifluoromethyl sulfides through AgSCF₃-mediated direct trifluoromethylthiolation has been developed. The reaction of the alkynyl iodides by CuI with 4,4′-di-tert-butyl-2,2′-bipyridine is performed under mild reaction conditions. This transformation efficiently affords aryl or alkyl acetenyl trifluoromethyl sulfides with good reaction yields, broad substrate scope, excellent compatibility and operational simplicity.

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agscf3介导的炔基碘化物直接三氟甲基硫化反应制备芳基和烷基乙基三氟甲基硫化物

提出了一种通过agscf3介导直接三氟甲基硫基化合成乙基三氟甲基硫化物的实用方法。在温和的反应条件下，CuI与4,4′-二叔丁基-2,2′-联吡啶反应了炔基碘化物。这种转化有效地提供了芳基或烷基乙酰基三氟甲基硫化物，反应产率好，底物范围广，相容性好，操作简单。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.