Seroprevalence and associated risk factors of selected arboviruses at Namanga and Mutukula cross-border areas in Tanzania

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-09-01 DOI:10.1016/j.ijregi.2025.100719

Remidius Kamuhabwa Kakulu , Ferdinand Ndunguru , Sima Rugarabamu , Ambele Mwafulango , Khalid Massa , Esther Gwae Kimaro , Emmanuel Abraham Mpolya

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Abstract

Objectives

Dengue (DENV), Chikungunya (CHIKV), and West Nile (WNV) viruses are among the major mosquito-borne arboviral threats in East Africa. This study assessed seroprevalence and risk factors for DENV, CHIKV, and WNV among residents of Mutukula and Namanga cross borders in Tanzania.

Methods

Blood samples were collected from 450 participants and tested using an enzyme-linked immunosorbent assay for anti-viral immunoglobulin G and M (IgG and IgM) antibodies. Descriptive and multivariate logistic regression analyzed risk factors.

Results

Overall seroprevalence was 12.4% for DENV, 10.7% for CHIKV, and 10.2% for WNV. Namanga had higher IgM seroprevalences (DENV: 9.7%, CHIKV: 6.9%, and WNV: 6.3%) than Mutukula (DENV: 5.6%, CHIKV: 5.3%, WNV: 5. 9%). IgG seropositivity for CHIKV was linked to a history of travel abroad (adjusted odds ratio [AOR] 7.3, 95% confidence interval [CI] 1.01-54.6), mosquito exposure (AOR 2.8, 95% CI 1.01-7.7), and being female (AOR 6.1, 95% CI 1.3-28). IgM seropositivity was influenced by education, with secondary levels reducing risk (AOR 0.11, 95% CI 0.02-0.64 for DENV; AOR 0.06, 95% CI 0.1-0.6 for CHIKV).

Conclusion

This study provides the first evidence of WNV exposure in Tanzania and specific cross-border seroprevalences for DENV and CHIKV transmission. To mitigate the risks, Integrated vector control and enhanced surveillance are highly recommended.

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坦桑尼亚纳曼加和穆图库拉跨境地区选定虫媒病毒的血清流行率和相关危险因素

目的登革热病毒（DENV）、基孔肯雅病毒（CHIKV）和西尼罗河病毒（WNV）是东非主要的蚊媒虫媒病毒威胁。本研究评估了坦桑尼亚Mutukula和Namanga跨境居民中DENV、CHIKV和西尼罗河病毒的血清患病率和危险因素。方法采用酶联免疫吸附法检测450例患者的抗病毒免疫球蛋白G和M （IgG和IgM）抗体。描述性和多变量logistic回归分析了危险因素。结果DENV、CHIKV和WNV的总血清阳性率分别为12.4%、10.7%和10.2%。Namanga的IgM血清患病率（DENV: 9.7%, CHIKV: 6.9%, WNV: 6.3%）高于Mutukula （DENV: 5.6%, CHIKV: 5.3%, WNV: 5%）。9%)。猪流感病毒IgG血清阳性与出国旅行史（调整优势比[AOR] 7.3, 95%可信区间[CI] 1.01-54.6）、蚊虫暴露（AOR 2.8, 95% CI 1.01-7.7）和女性（AOR 6.1, 95% CI 1.3-28）有关。IgM血清阳性受教育程度的影响，中等教育水平降低风险（DENV的AOR为0.11,95% CI 0.02-0.64； CHIKV的AOR为0.06,95% CI 0.1-0.6）。结论本研究提供了坦桑尼亚西尼罗河病毒暴露的第一个证据，以及DENV和CHIKV传播的特定跨境血清流行率。为减轻风险，强烈建议综合病媒控制和加强监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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