Smart hydrogel sensors: advancing from highly sensitive detection to an integrated platform for miRNA diagnosis and treatment

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-09-03 DOI:10.1016/j.trac.2025.118450

Xiaoyu Zhang, Yuanke Zhang, Wenjing Wei, Guixia Ling, Peng Zhang

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引用次数: 0

Abstract

Abnormal expression of microRNAs (miRNAs), as disease-specific biomarkers, contains crucial pathological information. Their accurate detection facilitates early intervention, vital for warning and diagnosing major diseases like cancer. This review focuses on innovative applications of multifunctional hydrogel sensors in miRNA detection. It systematically analyzes hydrogel materials’ functional design strategies, highlights progress in signal amplification mechanisms, and wearable integration technologies. Meanwhile, it explores the potential of this technology in the integration of diagnosis and treatment, and proposes solutions to the current bottlenecks and challenges of detection technologies in combination with actual scenario needs. Finally, it envisions integrating multimodal sensing with precision medical closed loops to build an intelligent miRNA detection platform. This offers theoretical support and practical methods for developing highly sensitive, portable systems, significantly promoting innovation in clinical early diagnosis technologies.

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智能水凝胶传感器：从高灵敏度检测向miRNA诊疗一体化平台迈进

microRNAs （miRNAs）作为疾病特异性的生物标志物，其异常表达包含重要的病理信息。它们的准确检测有助于早期干预，对癌症等重大疾病的预警和诊断至关重要。本文综述了多功能水凝胶传感器在miRNA检测中的创新应用。系统分析了水凝胶材料的功能设计策略，重点介绍了信号放大机制和可穿戴集成技术的进展。同时，探索该技术在诊疗一体化方面的潜力，结合实际场景需求，针对当前检测技术的瓶颈和挑战提出解决方案。最后，设想将多模态传感与精密医疗闭环相结合，构建智能miRNA检测平台。这为开发高灵敏度便携式系统提供了理论支持和实践方法，极大地促进了临床早期诊断技术的创新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.