Engineered VTA dopaminergic neurons offer a new path to treating depression

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-09-04 DOI:10.1016/j.stem.2025.08.007

Rossella Ventura

引用次数: 0

Abstract

Dysfunction of A10 midbrain dopaminergic (mDA) neurons is linked to psychiatric disorders, such as depression. In this issue, Yan et al.¹ present an efficient method for differentiating human pluripotent stem cells into A10-like mDA neurons. Activation of grafted A10-like neurons into the mouse mesolimbic circuit alleviates depression-like symptoms.

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工程VTA多巴胺能神经元为治疗抑郁症提供了一条新的途径

A10中脑多巴胺能（mDA）神经元的功能障碍与精神疾病有关，如抑郁症。在本期中，Yan等人1提出了一种将人多能干细胞分化为a10样mDA神经元的有效方法。将a10样神经元移植到小鼠中脑边缘回路中激活可减轻抑郁样症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.