Serum Biglycan and Decorin as Biomarkers for Preterm Birth: A Prospective Cohort Study

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada Pub Date : 2025-08-26 DOI:10.1016/j.jogc.2025.103086

Sundas Akram Mphil, Kaleem Maqsood PhD, Javeria Malik PhD, Nabila Roohi PhD

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引用次数: 0

Abstract

Objectives

Preterm birth (PTB) affects 10% of pregnancies worldwide, causing significant neonatal morbidity and mortality. Biglycan and decorin, essential proteoglycans in fetal membranes, are linked to spontaneous PTB pathophysiology. This study investigates their potential as biomarkers for spontaneous PTB.

Methods

This study included 500 pregnant women from various hospitals. Blood samples were collected, and participants were followed up until delivery. Pregnant women were categorized into groups based on gestational age at birth: moderate PTB, very PTB (vPTB), and term birth (control group). Serum levels of biglycan and decorin were measured using enzyme-linked immunosorbent assay kits. Statistical analysis included analysis of variance, logistic regression, and receiver operating characteristic curve evaluation using SPSS.

Results

Serum levels of biglycan were higher in the vPTB group in the second (82.49 ± 2.86 pg/mL, P = 0.0012) and third trimesters (81.17 ± 2.01 pg/mL, P = 0.0097). In both trimesters, decorin levels were lower in the vPTB group (second: 36.32 ± 0.90 ng/mL, P = 0.0013; third: 34.25 ± 1.86 ng/mL, P = 0.0023). Receiver operating characteristic curve analysis showed fair discriminatory power for decorin in the third trimester (area under the curve = 0.70, P = 0.0021). Multinomial logistic regression further confirmed that both biomarkers (biglycan: OR 1.034, P = 0.001; decorin: OR 0.914, P = 0.001) were significant predictors of PTB.

Conclusions

Reduced amount of decorin and increased concentration of biglycan during pregnancy were associated with enhanced risk of spontaneous PTB. These results support the potential of early gestation serum glycoprotein complex as a predictive model for spontaneous PTB.

查看原文本刊更多论文

血清Biglycan和Decorin作为早产的生物标志物：一项前瞻性队列研究。

导读：早产（PTB）影响全球10%的妊娠，造成显著的新生儿发病率和死亡率。Biglycan和decorin是胎膜中必需的蛋白聚糖，与自发性肺结核的病理生理有关。本研究探讨了它们作为自发性肺结核生物标志物的潜力。方法：本研究包括500名来自不同医院的孕妇。研究人员采集了参与者的血液样本，并对他们进行了随访，直到分娩。孕妇根据出生时的胎龄分为三组：中度早产（mPTB）、重度早产（vPTB）和足月分娩（对照组）。采用酶联免疫吸附试验（ELISA）检测血清多糖和decorin水平。统计分析采用方差分析、logistic回归及SPSS进行ROC曲线评价。结果：vPTB组在妊娠中期（82.49±2.86 pg/mL, P = 0.0012）和妊娠晚期（81.17±2.01 pg/mL, P = 0.0097）血清biglycan水平均较高。vPTB组的Decorin水平在两个妊娠期均较低（第二组：36.32±0.90 ng/mL, P = 0.0013；第三组：34.25±1.86 ng/mL, P = 0.0023）。ROC曲线分析显示，妊娠晚期decorin的区分力较好（AUC = 0.70, P = 0.0021）。多项logistic回归进一步证实了这两种生物标志物（biglycan: OR;1.034, P = 0.001）和decorin: OR； 0.914, P = 0.001)是早产的显著预测因子。结论：妊娠期decorin量的减少和biglycan浓度的升高与自发性早产的风险增加有关。这些结果支持早期妊娠血清糖蛋白复合物作为自发性早产的预测模型的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of obstetrics and gynaecology Canada OBSTETRICS & GYNECOLOGY-

CiteScore

3.30

自引率

5.60%

发文量

302

审稿时长

32 days

期刊介绍： Journal of Obstetrics and Gynaecology Canada (JOGC) is Canada"s peer-reviewed journal of obstetrics, gynaecology, and women"s health. Each monthly issue contains original research articles, reviews, case reports, commentaries, and editorials on all aspects of reproductive health. JOGC is the original publication source of evidence-based clinical guidelines, committee opinions, and policy statements that derive from standing or ad hoc committees of the Society of Obstetricians and Gynaecologists of Canada. JOGC is included in the National Library of Medicine"s MEDLINE database, and abstracts from JOGC are accessible on PubMed.