Two-Year Results of Percutaneous Endocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy

IF 1.9 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Catheterization and Cardiovascular Interventions Pub Date : 2025-08-28 DOI:10.1002/ccd.70119

NingNing Zheng, YiYuan Chen, YongBing Fu, Feng Xue, FangFang Zhang, Lin Ling, TingBo Jiang

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引用次数: 0

Abstract

Background

Hypertrophic obstructive cardiomyopathy (HOCM) is a hereditary myocardial disease. Percutaneous endocardial septal radiofrequency ablation (PESA) is an innovative approach for treating HOCM. Consequently, we present the outcomes of the PESA for HOCM.

Methods

This study included 20 patients with HOCM who received PESA. The primary outcomes include the control rate of the left ventricular outflow tract gradient (LVOTG) at rest and following the Valsalva maneuver and changes in New York Heart Association (NYHA) function. Secondary outcomes include changes in interventricular septal thickness (IVST), left ventricular ejection fraction (LVEF), pulmonary artery systolic pressure (PASP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP). In addition, this study assessed the incidence of complications during the perioperative period, the operation time of the PESA, and hospital stays.

Results

After 2 years, the LVOTG for patients decreased 54% at rest and 55% after the Valsalva maneuver. In addition, the NYHA functional index increased from 3.25 ± 0.55 to 1.95 ± 0.88, and 15 patients (75%) achieved NYHA Class I/Ⅱ. The LVEF of patients significantly increased from 63.95 ± 6.29% to 65.75 ± 3.39%, the PASP decreased from 32.50 (31.00, 40.50) mmHg to 23.50 (19.50, 28.50) mmHg, the NT-proBNP decreased from 388.90 (278.80, 1039.00) ng/mL to 227.4 (121.6, 499.6) ng/mL, and the IVST decreased from 17.20 ± 3.72 mm to 15.80 ± 3.14 mm. Importantly, no patients needed pacemaker treatment. The operative time for the PESA was 186.63 ± 22.47 min, and the median postoperative hospital stay for patients was 10.00 days.

Conclusions

PESA could reduce the LVOTG with the advantages of a low risk of arrhythmias, minimal trauma, rapid postoperative recovery, and shorter hospital stays.

Abstract Image

查看原文本刊更多论文

经皮心内膜间隔射频消融治疗肥厚性梗阻性心肌病的两年结果。

背景：肥厚性梗阻性心肌病（HOCM）是一种遗传性心肌疾病。经皮心内膜间隔射频消融术（PESA）是治疗HOCM的一种创新方法。因此，我们提出了HOCM的PESA结果。方法：本研究纳入20例接受PESA治疗的HOCM患者。主要结果包括静息和Valsalva操作后左心室流出道梯度（LVOTG）控制率和纽约心脏协会（NYHA）功能的变化。次要结局包括室间隔厚度（IVST）、左室射血分数（LVEF）、肺动脉收缩压（PASP）和n端前b型利钠肽（NT-proBNP）的变化。此外，本研究还评估了围手术期并发症的发生率、PESA的手术时间和住院时间。结果：2年后，患者的LVOTG在休息时下降54%，在Valsalva手法后下降55%。NYHA功能指数由3.25±0.55提高到1.95±0.88,15例（75%）患者达到NYHA I级/Ⅱ。患者LVEF由63.95±6.29%上升至65.75±3.39%，PASP由32.50 (31.00,40.50)mmHg下降至23.50 (19.50,28.50)mmHg， NT-proBNP由388.90 (278.80,1039.00)ng/mL下降至227.4 (121.6,499.6)ng/mL， IVST由17.20±3.72 mm下降至15.80±3.14 mm。重要的是，没有患者需要心脏起搏器治疗。PESA手术时间为186.63±22.47 min，患者术后中位住院时间为10.00 d。结论：PESA可降低LVOTG，具有心律失常风险低、创伤小、术后恢复快、住院时间短等优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Catheterization and Cardiovascular Interventions 医学-心血管系统

CiteScore

5.40

自引率

8.70%

发文量

419

审稿时长

2 months

期刊介绍： Catheterization and Cardiovascular Interventions is an international journal covering the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability.