Therapeutic efficacy of the polidocanol versus pingyangmycin in the treatment of maxillofacial vascular disorders.

Abstract

ObjectiveTo study the clinical therapeutic effect of polidocanol injection in the treatment of maxillofacial vascular disorders, and to compare the therapeutic effect with that of Pingyangmycin.MethodsA total of 300 patients with maxillofacial vascular abnormalities from March 14, 2021 to January 9, 2022 were selected from a hospital and divided into hemangioma group, lymphatic vessel malformation group and venous malformation group. The treatment was divided into two groups: Pingyangmycin and polidocanol injection. By comparing the pain coefficient, adverse reactions, therapeutic effect and the effect of the two drugs on cells, the therapeutic effect and safety of the two drugs were comprehensively analyzed.ResultsUnder the same conditions, the infiltration rates of 5-bromodeoxyuracil into lymphoendothelial cells with different concentrations of polidocanol injection were 0.62%, 0.59%, 0.36%, 0.18% and 0.15%, respectively, which were better than Pingyangmycin. The protein kinase C expression levels of polidocanol injection with different concentrations were 1.01, 1.21, 1.02, 0.75 and 0.61, respectively, which were better than Pingyangmycin. The adverse reaction rate, cure rate, effective rate and total effective rate of hemangioma patients treated with polidocanol injection were 88.64%, 80.77%, 94.23% and 100.00%, respectively. The adverse reaction rate, cure rate, effective rate and total effective rate were 91.30%, 71.74%, 84.78% and 95.65%, respectively. The adverse reaction rate, cure rate, effective rate and total effective rate of venous malformation patients were 90.00%, 92.00%, 98.00% and 100.00%, respectively. The adverse reaction rate, cure rate, effective rate and total effective rate of hemangioma patients treated with Pingyangmycin were 92.59%, 64.81%, 88.89% and 98.15%, respectively. The adverse reaction rate, cure rate, effective rate and total effective rate of patients with lymphatic vessel malformation were 94.00%, 54.00%, 84.00% and 94.00% respectively. The adverse reaction rate, cure rate, effective rate and total effective rate of venous malformation patients were 95.83%, 75.00%, 91.67% and 100.00%, respectively.ConclusionPolidocanol injection is better than Pingyangmycin in the treatment of maxillofacial vascular disorders, and the drug is milder, less adverse reactions and higher safety.