Prevalence of human onchocerciasis in Ethiopia: a systematic review and meta-analysis.

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African health sciences Pub Date : 2025-06-01 DOI:10.4314/ahs.v25i2.3

Tadesse Hailu, Getaneh Alemu, Megbaru Alemu

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Abstract

Background: Onchocerciasis is a vector-borne disease caused by the tissue nematode Onchocerca volvulus. Despite its importance for targeted intervention, the national prevalence is not well addressed in Ethiopia.

Objective: This review aimed to determine the pooled prevalence of human onchocerciasis in Ethiopia.

Methods: All literature published from 1973 to July 2022 were included in the present review A systematic review and meta-analysis was done following PRISMA guideline and checklists. Studies conducted on the prevalence of onchocerciasis in Ethiopia were searched from PubMed, Google Scholar, Scopus, ScienceDirect, and MEDLINE databases. Comprehensive meta-analysis version 2.2 software was used to calculate the pooled prevalence. Heterogeneity between studies was assessed using Cochrane Q test and I2 test statistics based on the random effects model.

Results: Twenty-one studies, which recruited a total of 14,983 participants, were included in the present review. The overall pooled prevalence of Onchocerca volvulus in Ethiopia was 31.8% using the random effect model. The heterogeneity between studies was high and significant (Q = 2881.2, I2 = 99.3%, P-value < 0.001).

Conclusions: The prevalence of onchocerciasis is high in Ethiopia, despite the implementation of prevention and control measures. Therefore, the existing mass drug administration program should be strengthened.

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埃塞俄比亚人盘尾丝虫病流行：系统回顾和荟萃分析

背景：盘尾丝虫病是由组织线虫盘尾丝虫病引起的媒介传播疾病。尽管它对有针对性的干预很重要，但在埃塞俄比亚，全国流行情况没有得到很好的解决。目的：本综述旨在确定埃塞俄比亚人盘尾丝虫病的总流行率。方法：本综述纳入1973年至2022年7月发表的所有文献，按照PRISMA指南和清单进行系统评价和荟萃分析。从PubMed、谷歌Scholar、Scopus、ScienceDirect和MEDLINE数据库中检索有关埃塞俄比亚盘尾丝虫病患病率的研究。采用2.2版综合meta分析软件计算合并患病率。基于随机效应模型，采用Cochrane Q检验和I2检验统计量评估研究间异质性。结果：本综述纳入了21项研究，共招募了14983名参与者。采用随机效应模型，埃塞俄比亚盘尾丝虫病总流行率为31.8%。研究间异质性高且显著（Q = 2881.2, I2 = 99.3%， p值< 0.001）。结论：尽管采取了预防和控制措施，但埃塞俄比亚盘尾丝虫病的流行率仍然很高。因此，现有的大规模药物管理程序应得到加强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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African health sciences

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