{"title":"Clinical comparison of simultaneous integrated and sequential boost IMRT of tumor bed after breast conserving surgery.","authors":"Minghai Shao, Caiping Jiang, Yunxiang Yao, Weifang Yang, Haijian Jia, Yichao Shen, Yanli Wang, Bin Yu","doi":"10.4314/ahs.v25i2.20","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To explore the clinical effect compare between the simultaneous-integrated boost and sequential-boost intensity modulated radiotherapy in early breast cancer patients after breast conserving surgery.</p><p><strong>Methodology: </strong>According to the different postoperative radiotherapy methods, 66 early breast cancer patients after breast-conserving surgery were divided into two groups, 34 in the simultaneous-integrated boost group and 32 in the sequential-boost intensity group. Adverse reactions, cosmetic effects, local recurrence rate, progression-free survival and overall survival rates were compared.</p><p><strong>Results: </strong>No statistical significance in the incidence of acute skin reaction, advanced skin reaction, myelosuppression, radiation pneumonia and other adverse reactions between two groups were observed. The fine rate of simultaneous-integrated boost group was slightly better than the sequential-boost intensity group. And the follow-up rate of the two groups was 100%. The progression-free survival rate of the simultaneous-integrated boost group and the sequential-boost intensity group were 100% and 96.88%, respectively; The overall survival rates of the two groups were all 100%; One patient in the sequential-boost intensity group had recurrence (3.13%), while none in the simultaneous-integrated boost group. No significant difference in local recurrence rate, progression-free survival and overall survival rates in the two groups were found.</p><p><strong>Conclusion: </strong>Simultaneous-integrated boost ensures breast appearance and survival without added radiotherapy side effects vs sequential-boost intensity.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"153-160"},"PeriodicalIF":0.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361936/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"African health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ahs.v25i2.20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background: To explore the clinical effect compare between the simultaneous-integrated boost and sequential-boost intensity modulated radiotherapy in early breast cancer patients after breast conserving surgery.
Methodology: According to the different postoperative radiotherapy methods, 66 early breast cancer patients after breast-conserving surgery were divided into two groups, 34 in the simultaneous-integrated boost group and 32 in the sequential-boost intensity group. Adverse reactions, cosmetic effects, local recurrence rate, progression-free survival and overall survival rates were compared.
Results: No statistical significance in the incidence of acute skin reaction, advanced skin reaction, myelosuppression, radiation pneumonia and other adverse reactions between two groups were observed. The fine rate of simultaneous-integrated boost group was slightly better than the sequential-boost intensity group. And the follow-up rate of the two groups was 100%. The progression-free survival rate of the simultaneous-integrated boost group and the sequential-boost intensity group were 100% and 96.88%, respectively; The overall survival rates of the two groups were all 100%; One patient in the sequential-boost intensity group had recurrence (3.13%), while none in the simultaneous-integrated boost group. No significant difference in local recurrence rate, progression-free survival and overall survival rates in the two groups were found.
Conclusion: Simultaneous-integrated boost ensures breast appearance and survival without added radiotherapy side effects vs sequential-boost intensity.
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