Associations of Metal Mixtures During Early Pregnancy With Midlife Obesity and Body Composition: A Prospective Study

IF 4.7 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Pub Date : 2025-08-26 DOI:10.1002/oby.24368
Mingyu Zhang, Izzuddin M. Aris, Andres Cardenas, Sheryl L. Rifas-Shiman, Pi-I Debby Lin, Long H. Ngo, Emily Oken, Stephen P. Juraschek, Marie-France Hivert
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引用次数: 0

Abstract

Objective

To examine the prospective associations of metal mixtures during pregnancy with midlife adiposity and explore metal-folate interactions.

Methods

In 500 participants from Project Viva, we measured six non-essential metals (arsenic, barium, cadmium, cesium, mercury, and lead) and five essential metals (copper, magnesium, manganese, selenium, and zinc) in red blood cells and folate in plasma collected during early pregnancy (mean gestational age: 10.0 weeks; mean age: 32.9 years). We assessed midlife (mean age: 51.2 years) adiposity using BMI and dual-energy X-ray absorptiometry (DXA) measures. We used multivariable-adjusted linear and multinomial logistic regression models to analyze individual exposures and Bayesian kernel machine regression to examine exposure mixtures.

Results

Higher arsenic, cesium, and mercury levels were associated with lower midlife DXA percentage fat, total fat mass index, and/or trunk fat mass index, even after adjustments for diet in pregnancy. We observed an antagonistic interaction between folate and arsenic: arsenic was associated with higher obesity risk at lower folate levels but lower obesity risk at higher folate levels. The essential metal mixture tended to be associated with lower midlife BMI and obesity risk.

Conclusions

Higher pregnancy levels of arsenic, cesium, mercury, and the mixture of essential metals were associated with lower midlife adiposity.

Abstract Image

妊娠早期金属混合物与中年肥胖和身体组成的关系:一项前瞻性研究。
目的:探讨孕期金属混合物与中年肥胖的潜在关联,并探讨金属-叶酸的相互作用。方法:在500名来自Viva项目的参与者中,我们测量了红细胞中的六种非必需金属(砷、钡、镉、铯、汞和铅)和五种必需金属(铜、镁、锰、硒和锌),以及在妊娠早期(平均胎龄:10.0周;平均年龄:32.9岁)收集的血浆中的叶酸。我们使用BMI和双能x线吸收仪(DXA)测量来评估中年(平均年龄:51.2岁)的肥胖。我们使用多变量调整线性和多项逻辑回归模型来分析个体暴露,并使用贝叶斯核机回归来检查暴露混合物。结果:较高的砷、铯和汞水平与较低的中年DXA百分比脂肪、总脂肪质量指数和/或躯干脂肪质量指数相关,即使在孕期调整饮食后也是如此。我们观察到叶酸和砷之间的拮抗相互作用:叶酸水平较低时,砷与较高的肥胖风险相关,而叶酸水平较高时,肥胖风险较低。这种必需的金属混合物往往与较低的中年体重指数和肥胖风险有关。结论:较高的孕期砷、铯、汞和必需金属混合物水平与较低的中年肥胖有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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