Prognostic factors for postoperative macular microcirculation remodeling in idiopathic full–thickness macular hole

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-08-21 DOI:10.1016/j.pdpdt.2025.104767

Jingling Zou , Nan Wang , Feng Zhang , Haiyan Lian , Jun Zeng , Yan Yang

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Abstract

Purpose

To investigate the features of the macular microcirculation using optical coherence tomography angiography (OCTA) in surgically closed idiopathic full–thickness macular hole (IFTMH) and the correlated independent prognostic factors for postoperative macular microcirculation remodeling.

Methods

Twenty–seven eyes of 27 patients after successful IFTMH surgery that were followed for 6 months and 27 eyes of 27 age– and gender–matched healthy subjects were included. Patients with IFTMH and healthy subjects were examined using OCTA. Macular vessel density (VD), foveal avascular zone (FAZ) area of superficial capillary plexus (SCP), and flow area of outer retina and choroid were analyzed. Best–corrected visual acuity (BCVA) was evaluated before and 6 months after the surgery.

Results

The BCVA improved in eyes with IFTMH after the surgery (p < 0.001). Postoperative VD was significantly lower in eyes with IFHMH compared with the normal control eyes (p < 0.001). The mean flow area of the outer retina in eyes that underwent IFTMH surgery was significantly larger than normal control eyes (p < 0.05), while the mean flow area of choroid capillary in postoperative IFTMH was significantly lower (p < 0.01). Foveal VD was negatively correlated with both minimal and basal diameters (r = −0.473, p < 0.05; r = −0.504, p < 0.01). FAZ area was significantly positively correlated with both minimal and basal diameters (r = 0.635, p < 0.001; r = 0.606, p < 0.01). Additionally, the age of IFTMH was negatively correlated with the postoperative whole VD (r = –0.440, p < 0.05) and positively correlated with the FAZ area (r = 0.382, p < 0.05).

Conclusion

Macular capillary plexuses observed by OCTA in eyes after IFTMH surgery had different characteristics compared to normal control eyes. Preoperative IFTMH characteristics can serve as prognostic factors for postoperative macular microcirculation remodeling.

查看原文本刊更多论文

特发性全层黄斑孔术后黄斑微循环重构的预后因素分析。

目的：应用光学相干断层血管造影（OCTA）研究手术封闭特发性全层黄斑孔（IFTMH）的黄斑微循环特征及术后黄斑微循环重构的相关独立预后因素。方法：选取27例IFTMH手术成功患者27只眼，随访6个月；选取27例年龄、性别匹配的健康受试者27只眼。用OCTA检查IFTMH患者和健康者。分析黄斑血管密度（VD）、浅毛细血管丛（SCP）中央凹无血管区（FAZ）面积、外视网膜及脉络膜的流动面积。术前和术后6个月评估最佳矫正视力（BCVA）。结果：IFTMH术后BCVA改善（p < 0.001）。与正常对照眼相比，IFHMH眼术后VD明显降低（p < 0.001）。IFTMH术后眼外视网膜平均流过面积显著大于正常对照眼（p < 0.05），脉络膜毛细血管平均流过面积显著低于正常对照眼（p < 0.01）。r = -0.504,p < 0.01; r = -0.473,p < 0.05)。FAZ面积与最小直径和基本直径均呈极显著正相关（r = 0.635,p < 0.001; r = 0.606,p < 0.01）。IFTMH年龄与术后全VD呈负相关（r = -0.440,p < 0.05），与FAZ面积呈正相关（r = 0.382,p < 0.05）。结论：IFTMH术后眼的OCTA观察到黄斑毛细血管丛的特征与正常对照眼不同。术前IFTMH特征可作为术后黄斑微循环重构的预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.