Acute macular neuroretinopathy in COVID-19 patients: Short-term prospective follow-up observation

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-08-19 DOI:10.1016/j.pdpdt.2025.104752

Ting Mei , Xuhui Chen , Qi Zhang , Jin Gong

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引用次数: 0

Abstract

Purpose

This study aims to characterize the multimodal imaging findings and clinical features of acute macular neuroretinopathy (AMN) in a series of coronavirus disease 2019 (COVID-19) patients from China.

Methods

In this observational study, a total of 18 patients (30 eyes) with post-COVID-19 infection presenting as AMN were enrolled between December 2022 and May 2024 and underwent a minimum of 12 months of ophthalmic follow-up. Multimodal imaging features following severe acute respiratory syndrome coronavirus 2 infection were evaluated by infrared (IR) reflectance imaging, ultrawide-field scanning laser ophthalmoscopy, spectral-domain optical coherence tomography (SD-OCT), optical coherence tomography angiography, visual field testing, and fundus fluorescein angiography.

Results

Scotomas were present in all 18 patients (30 eyes) at the initial visit. IR reflectance imaging revealed localized areas of hyporeflectivity in the macular region in 5 patients (8 eyes). SD-OCT scans demonstrated hyper-reflective changes within the photoreceptor layer and disruption of its normal laminar architecture in all 18 patients (30 eyes). All cases in this series exhibited signs of classic maculopathy. Notably, these abnormalities persisted for at least 12 months in all affected eyes.

Conclusion

These data suggest that AMN is a significant ocular manifestation in patients with COVID-19, characterized by persistent scotomas lasting at least 12 months.

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COVID-19患者急性黄斑神经视网膜病变的短期前瞻性随访观察

目的：本研究旨在描述中国一系列冠状病毒病2019 （COVID-19）患者急性黄斑神经视网膜病变（AMN）的多模式影像学表现和临床特征。方法：在这项观察性研究中，共有18例（30只眼睛）在2022年12月至2024年5月期间以AMN表现的covid -19感染后患者入组，并进行了至少12个月的眼科随访。通过红外（IR）反射成像、超宽场扫描激光检眼镜、光谱域光学相干断层扫描（SD-OCT）、光学相干断层扫描血管造影、视野测试和眼底荧光素血管造影评估严重急性呼吸综合征冠状病毒2型感染后的多模态影像学特征。结果：18例患者（30只眼）初次就诊时均存在暗点。红外反射成像显示5例（8眼）黄斑区局部低反射率。SD-OCT扫描显示，所有18例患者（30只眼）的光感受器层发生超反射变化，其正常层流结构被破坏。所有病例均表现出典型黄斑病变的症状。值得注意的是，这些异常在所有受影响的眼睛中持续了至少12个月。结论：这些数据提示AMN是COVID-19患者的一个重要眼部表现，其特征是持续存在的暗斑至少持续12个月。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.