The global genomic landscape of hypervirulent Klebsiella pneumoniae from 1932 to 2021.

IF 4.5 Q1 MICROBIOLOGY

mLife Pub Date : 2025-08-24 eCollection Date: 2025-08-01 DOI:10.1002/mlf2.70029

Xiaoyuan Jiang, Shuangshuang Li, Cuidan Li, Zhe Yin, Fangzhou Chen, Lingfei Hu, Tianyu Lu, Xiaoqiang Liu, Yinyu Wang, Guannan Ma, Xiaoyu Wang, Fei Chen, Dongsheng Zhou

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Abstract

The global spread of hypervirulent Klebsiella pneumoniae (hvKp) poses a serious public health threat. In this study, we conducted genomic epidemiology analysis on 2097 global hvKp isolates, including our 900 isolates sequenced through the Illumina platform (177 of them fully sequenced through PacBio platform), representing the most comprehensive genomic analysis of hvKp to date. Our results identified six dominant clonal groups (CGs), particularly including CG23 and CG258, and 17 major virulence determinant combinations (VDCs) comprising 10 virulence gene profiles (VGPs), four types of virulence plasmids, four ICEKp variants, Tn7399, and all_island. Each CG harbored distinct advantageous VDCs, indicating strong genomic correlation and co-evolution. Additionally, the phylogeny and evolutionary history of CG23 and CG258 were characterized in depth. Notably, 41.58% of the 2097 isolates were multidrug-resistant and 33.29% were carbapenem-resistant, indicating serious antimicrobial resistance. Overall, our study provides a global genomic landscape of hvKp, emphasizing the genetic basis for their global dissemination and the need for precise prevention and control.

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从1932年到2021年，全球高致病性肺炎克雷伯菌的基因组景观。

高致病性肺炎克雷伯菌（hvKp）的全球传播构成了严重的公共卫生威胁。在这项研究中，我们对全球2097株hvKp进行了基因组流行病学分析，其中900株通过Illumina平台测序（其中177株通过PacBio平台完全测序），代表了迄今为止最全面的hvKp基因组分析。我们的研究结果确定了6个优势克隆群（CGs），特别是包括CG23和CG258，以及17个主要毒力决定组合（VDCs），包括10个毒力基因谱（VGPs）， 4种毒力质粒，4种ICEKp变体，Tn7399和all_island。每个CG都有独特的优势vdc，表明强烈的基因组相关性和共同进化。此外，还对CG23和CG258的系统发育和进化历史进行了深入的研究。值得注意的是，2097株中有41.58%的菌株多重耐药，33.29%的菌株对碳青霉烯类药物耐药，表明耐药性严重。总之，我们的研究提供了hvKp的全球基因组图谱，强调了其全球传播的遗传基础和精确预防和控制的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

mLife

CiteScore

2.30

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0.00%

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