A comparative analysis of lamina Cribrosa curvature index values in different stages of diabetic retinopathy

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-08-21 DOI:10.1016/j.pdpdt.2025.104769

Mübeccel Bulut , Ali H Reyhan

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引用次数: 0

Abstract

Purpose

To compare lamina cribrosa structural parameters for diabetic retinopathy and evaluate the potential use of the lamina cribrosa curvature index (LCCI) as a biomarker for progression.

Methods

All participants underwent comprehensive ophthalmic examinations and optical coherence tomography (OCT) imaging of the optic nerve head. The following lamina cribrosa parameters were measured from high-resolution B-scan images; LCCI, lamina cribrosa curve depth (LCCD), anterior lamina cribrosa depth (ALCD), and lamina cribrosa thickness (LCT). The LCCI was calculated as the ratio of LCCD to Bruch’s membrane opening (BMO) width, multiplied by 100, and was used to assess posterior bowing of the lamina cribrosa.

Results

One hundred sixty eyes of 80 participants (mean age 57.3 ± 9.9 years) were analyzed. LCCI values were significantly lower in the proliferative diabetic retinopathy (PDR) group (7.34 ± 1.85 %) compared to the diabetic patients without retinopathy (9.91 ± 3.47 %) and the control (10.13 ± 3.26 %) group. LCCD was also lower in the PDR group (122.46 ± 27.51 µm), than in the diabetic patients without retinopathy (165.8 ± 55.19 µm) and the controls (161.94 ± 46.12 µm). ALCD was lowest in the PDR group (301.7 ± 37.01 µm) and highest in the controls (365.35 ± 57.78 µm). With the exception of BMO, neither HbA1c nor duration of diabetes exhibited significant correlations with any lamina cribrosa parameters.

Conclusion

Despite distinct pathophysiological patterns compared to other optic neuropathies, the LCCI reveals significant progressive changes that may serve as a valuable biomarker for disease progression in diabetic retinopathy.

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糖尿病视网膜病变不同阶段视网膜板曲率指数的比较分析。

目的：比较糖尿病视网膜病变的筛板结构参数，并评估筛板曲率指数（LCCI）作为进展生物标志物的潜在用途。方法：所有参与者均接受全面眼科检查和视神经头光学相干断层扫描（OCT）成像。通过高分辨率b扫描图像测量筛板参数：LCCI、筛板曲线深度（LCCD）、筛板前深度（ALCD）、筛板厚度（LCT）。LCCI计算为LCCD与Bruch膜开口（BMO）宽度之比乘以100，用于评估筛板后侧弯曲。结果：80名参与者共160只眼（平均年龄57.3 ± 9.9岁）。增殖性糖尿病视网膜病变（PDR）组的LCCI值（7.34 ± 1.85%）明显低于无视网膜病变的糖尿病患者（9.91 ± 3.47%）和对照组（10.13 ± 3.26%）。LCCD PDR组也较低(122.46 ±27.51  µm),糖尿病患者比无视网膜病变(165.8 ±55.19  µm)和控制(161.94 ±46.12  µm)。PDR组ALCD最低（301.7 ± 37.01 µm），对照组最高（365.35 ± 57.78 µm）。除BMO外，HbA1c和糖尿病病程均与任何筛板参数均无显著相关性。结论：尽管与其他视神经病变相比有不同的病理生理模式，但LCCI显示出显著的进行性变化，可能作为糖尿病视网膜病变疾病进展的有价值的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.