[Clinical and histological evaluation of three-dimensional printing individualized titanium mesh for alveolar bone defect repair].

Pengyu Zhao, Gang Chen, Yi Cheng, Chao Wang, Dan Chen, Haitao Huang
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Abstract

Objectives: To evaluate the osteogenic efficacy of three-dimensional printing individualized titanium mesh (3D-PITM) as a scaffold material in guided bone regeneration (GBR).

Methods: 1) Patients undergoing GBR for alveolar bone defects were enrolled as study subjects, and postoperative healing complications were recorded. 2) Postoperative cone beam computed tomography (CBCT) scans acquired at least 6 months post-surgery were used to calculate the percentage of actual bone formation volume. 3) Alveolar bone specimens were collected during the first-stage implant surgery for histomorphometric analysis. This analysis quantitatively measured the proportions of newly formed bone and newly formed unmineralized bone within the specimens. Specimens were categorized into three groups based on healing complications (good healing group, wound dehiscence group, 3D-PITM exposure group) to compare differences in the proportions of newly formed bone and newly formed unmineralized bone.

Results: 1) Twelve patients were included. Guided bone regeneration failed in one patient, and 3D-PITM exposure occurred in three patients (exposure rate: 25%). 2) The mean percentage of actual bone formation volume in the 11 successful guided bone regeneration cases was 95.23%±28.85%. 3) Histomorphometric analysis revealed that newly formed bone constituted 40.35% of the alveolar bone specimens, with newly formed unmineralized bone accounting for 13.84% of the newly formed bone. Intergroup comparisons showed no statistically significant differences (P>0.05) in the proportions of newly formed bone or newly formed unmineralized bone between the good healing group and the wound dehiscence group or the 3D-PITM exposure group.

Conclusions: 3D-PITM enables effective bone augmentation. Radiographic assessment demonstrated favorable bone formation volume, while histological analysis confirmed substantial formation of newly formed mineralized bone within the surgical site.

三维打印个体化钛网修复牙槽骨缺损的临床及组织学评价
目的:评价三维打印个性化钛网(3D-PITM)作为支架材料在引导骨再生(GBR)中的成骨效果。方法:1)选取牙槽骨缺损行GBR的患者作为研究对象,记录术后愈合并发症。2)术后至少6个月的锥形束计算机断层扫描(CBCT)用于计算实际骨形成体积的百分比。3)在种植体一期手术中采集牙槽骨标本进行组织形态学分析。该分析定量测量了标本中新形成的骨和新形成的未矿化骨的比例。根据愈合并发症将标本分为三组(愈合良好组、创面裂开组、3D-PITM暴露组),比较新生骨和新生未矿化骨比例的差异。结果:1)纳入12例患者。1例患者引导骨再生失败,3例患者出现3D-PITM暴露(暴露率25%)。2) 11例成功引导骨再生患者的实际骨形成体积平均百分比为95.23%±28.85%。3)组织形态学分析显示,新形成的骨占牙槽骨标本的40.35%,新形成的未矿化骨占新形成骨的13.84%。组间比较,愈合良好组与创面裂开组、3D-PITM暴露组新生骨或未矿化新生骨比例差异无统计学意义(P>0.05)。结论:3D-PITM可以实现有效的骨增强。放射学评估显示良好的骨形成体积,而组织学分析证实手术部位内新形成的矿化骨大量形成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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