A Systematic Review of Lifestyle Interventions for Neuropathy and Neuropathic Pain: Smoking Cessation.

IF 2 Q3 CLINICAL NEUROLOGY
NeuroSci Pub Date : 2025-08-07 DOI:10.3390/neurosci6030074
Michael Klowak, Rachel Lau, Mariyam N Mohammed, Afia Birago, Bethel Samson, Layla Ahmed, Camille Renee, Milca Meconnen, Ezra Bado, Aquilla Reid-John, Andrea K Boggild
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Abstract

Background: Neuropathic pain (NP), resulting from damage to the somatosensory nervous system, affects 7-10% of the global population and remains poorly managed despite available therapies. Smoking has been associated with increased pain severity and disease burden, yet its role in neuropathy/NP has not been systematically reviewed. This systematic review synthesizes the existing literature on smoking status and its relationship with neuropathy/NP incidence, prevalence, and severity. Methods: The review was conducted in accordance with PRISMA guidelines and included studies that assessed smoking consumption, dependency, quantity, and cessation in individuals with neuropathy/NP. Summary estimates were stratified by exposure type, and pooled odds ratios and relative risks were calculated. Results: Across 62 studies comprising cohort, case-control, and cross-sectional designs, smoking was consistently associated with greater NP prevalence and pain severity. Smoking dependency was linked to increased incidence, while cessation was associated with reduced risk of NP. Despite considerable heterogeneity and risk of bias, particularly from subjective exposure measurement and inconsistent classification, this relationship remained statistically significant. Conclusions: Findings support the role of smoking as a modifiable risk factor in various etiologies of neuropathy/NP. Cessation may represent a low-cost, low-risk, low-tech adjunctive therapy; however, further robust cessation interventional trials are needed, particularly for less common infectious causes of chronic NP such as leprosy.

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对神经病变和神经性疼痛的生活方式干预的系统综述:戒烟。
背景:由体感觉神经系统损伤引起的神经性疼痛(NP)影响了全球7-10%的人口,尽管有现有的治疗方法,但仍然管理不善。吸烟与疼痛严重程度和疾病负担增加有关,但其在神经病变/NP中的作用尚未系统回顾。本系统综述综合了有关吸烟状况及其与神经病变/NP发病率、患病率和严重程度的关系的现有文献。方法:本综述按照PRISMA指南进行,纳入了评估神经病变/NP患者吸烟消费、依赖、数量和戒烟的研究。根据暴露类型对总估计值进行分层,并计算合并优势比和相对风险。结果:在包括队列、病例对照和横断面设计的62项研究中,吸烟始终与更高的NP患病率和疼痛严重程度相关。吸烟依赖与发病率增加有关,而戒烟与NP风险降低有关。尽管存在相当大的异质性和偏倚风险,特别是主观暴露测量和不一致的分类,但这种关系仍然具有统计学意义。结论:研究结果支持吸烟在神经病变/NP的各种病因中作为可改变的危险因素的作用。戒烟可能是一种低成本、低风险、低技术含量的辅助治疗;然而,需要进一步强有力的戒烟干预试验,特别是对于慢性NP不太常见的感染性原因,如麻风病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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