Barriers and opportunities in biobank utilization: insights from a 3-year repeated cross-sectional survey of the Female Breast and Genital Disease with Microbiome Biobank Network in South Korea.

IF 1.4 Q3 MEDICINE, GENERAL & INTERNAL
Journal of Yeungnam medical science Pub Date : 2025-01-01 Epub Date: 2025-08-27 DOI:10.12701/jyms.2025.42.46
Sangzin Ahn, Hwa Jin Cho, Mi-Seon Kang, An Na Seo, Lucia Kim, Kyung Un Choi, Mee Sook Roh, Eun-Young Kim
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Abstract

Background: This study aimed to document the patterns, challenges, and opportunities for biobank utilization within the Female Breast and Genital Disease with Microbiome Biobank Network (FDMNet) in South Korea. Annual surveys (2022-2024) assessed researcher awareness, utilization patterns, barriers to access, research requirements, and interest in microbiome research.

Methods: Online questionnaires were distributed to staff members at five university hospitals participating in FDMNet. Data from 155 respondents across 3 years were analyzed using descriptive statistics for quantitative data. Qualitative feedback was examined using Uniform Manifold Approximation and Projection and natural language processing to identify the thematic clusters of user challenges.

Results: Despite high engagement with biobank resources (76% of the respondents), declining participation rates and interinstitutional collaborations were observed, particularly in 2024, amid the nationwide healthcare crisis. The major barriers to utilization included complex access procedures (31.0%), lack of process knowledge (23.9%), and concerns about Institutional Review Board approval (11.6%). Breast neoplasms (12.3%) and female genital neoplasms (11.0%) were the primary research interests, with blood (24.5%) and tissue (23.9%) samples being the most requested specimens. Most respondents (66.5%) expressed interest in microbiome research but reported insufficient knowledge.

Conclusion: These findings highlight the need for streamlined access procedures, improved researcher education, enhanced clinical data integration, and stronger governance structures to overcome existing barriers to biobank utilization. These insights can guide strategic improvements in biobank operations and resource allocation to serve the evolving needs of the research community better.

生物银行利用的障碍和机会:来自韩国女性乳房和生殖器疾病微生物组生物银行网络3年重复横断面调查的见解。
背景:本研究旨在记录韩国女性乳房和生殖器疾病微生物组生物库网络(FDMNet)中生物库利用的模式、挑战和机遇。年度调查(2022-2024)评估了研究人员对微生物组研究的认识、利用模式、获取障碍、研究要求和兴趣。方法:对参加FDMNet的五所大学医院的工作人员进行在线问卷调查。对155名调查对象3年间的数据进行了描述性统计分析。定性反馈使用统一流形逼近和投影和自然语言处理来确定用户挑战的主题集群。结果:尽管生物银行资源的参与度很高(76%的受访者),但观察到参与率和机构间合作的下降,特别是在2024年,在全国医疗保健危机中。使用的主要障碍包括复杂的访问程序(31.0%),缺乏过程知识(23.9%),以及对机构审查委员会批准的担忧(11.6%)。乳房肿瘤(12.3%)和女性生殖器肿瘤(11.0%)是主要的研究兴趣,血液(24.5%)和组织(23.9%)样本是最需要的样本。大多数受访者(66.5%)表示对微生物组研究感兴趣,但表示知识不足。结论:这些发现强调了简化获取程序、改善研究人员教育、加强临床数据整合和加强治理结构的必要性,以克服生物库利用的现有障碍。这些见解可以指导生物库操作和资源分配的战略改进,以更好地满足研究界不断变化的需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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