Anxiety and Depression in Mild and Moderate COPD Patients: An Observational, Cross-Sectional Study in Greece.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Effimia Kamariotou, Diamantis Chloros, Dionisios Spyratos, Dionisia Michalopoulou, Ioanna Tsiouprou, Lazaros Sichletidis
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Abstract

Background: In this study, we investigated patients in the early stages of COPD to support the hypothesis that symptoms of anxiety and depression are related to mild and moderate COPD and not only to the chronic complications that accompany severe disease.

Methods: A total of 250 mild to moderate COPD patients were randomly selected from a population of 5239 individuals who were part of a study on early COPD detection and smoking cessation that was carried out in Central Macedonia, Greece. An age-matched control group of three hundred current or former smokers was also included. A questionnaire was used for demographic data collection, along with the Hospital Anxiety and Depression Scale (HADS) questionnaire for the evaluation of anxiety (HADS-A) and depressive (HADS-D) symptoms.

Results: The COPD and non-COPD groups were similar in age, gender, and socioeconomic background. The majority of COPD patients were classified as Grade 1 or 2 and belonged to Group A or B according to the GOLD classification. Among the COPD patients, 19.6% had a score greater than 7 in the HADS-A subscale, 14% in the HADS-D subscale, and 10.8% in both, compared with 6%, 5%, and 5%, respectively, for the non-COPD individuals (p < 0.01). A regression analysis showed that the presence of at least one comorbidity (β = 0.43, p < 0.001) and the presence of at least one respiratory symptom (β = 0.49, p < 0.001) significantly predicted the total HADS score in the COPD group.

Conclusions: The prevalence of depression and anxiety symptoms in early COPD patients was greater in comparison to non-COPD smokers. Implementing routine screening for mood disorders using the HADS in mild to moderate COPD outpatients may improve overall disease management and patients' quality of life.

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轻、中度COPD患者的焦虑和抑郁:希腊的一项观察性横断面研究
背景:在这项研究中,我们调查了COPD早期阶段的患者,以支持焦虑和抑郁症状与轻度和中度COPD相关的假设,而不仅仅是伴随严重疾病的慢性并发症。方法:从5239名患者中随机选择250名轻度至中度COPD患者,这些患者是在希腊马其顿进行的早期COPD检测和戒烟研究的一部分。研究还包括一个年龄相当的对照组,由300名现在或曾经吸烟的人组成。使用问卷收集人口统计数据,并使用医院焦虑和抑郁量表(HADS)问卷评估焦虑(HADS-A)和抑郁(HADS- d)症状。结果:COPD组和非COPD组在年龄、性别和社会经济背景上相似。大多数COPD患者按照GOLD分级分为1级或2级,属于A组或B组。在COPD患者中,19.6%的HADS-A评分大于7分,14%的HADS-D评分大于7分,10.8%的HADS-D评分大于7分,而在非COPD患者中,这一比例分别为6%、5%和5% (p < 0.01)。回归分析显示,存在至少一种共病(β = 0.43, p < 0.001)和存在至少一种呼吸系统症状(β = 0.49, p < 0.001)可显著预测COPD组HADS总分。结论:与非COPD吸烟者相比,早期COPD患者抑郁和焦虑症状的患病率更高。在轻中度COPD门诊患者中使用HADS对情绪障碍进行常规筛查可以改善整体疾病管理和患者的生活质量。
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CiteScore
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