Impact of Obesity on Immunity to the Influenza Virus: Gut Microbiota, Mechanisms, and Novel Therapeutic Strategies.

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Xiaoyue Ji, Jing Sun
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引用次数: 0

Abstract

Obesity affects millions of individuals globally, and a deeper understanding of its associated physiological disturbances is essential for addressing key public health concerns. It has been demonstrated that the influenza virus possesses substantial global epidemic potential, with higher incidence rates observed in obese individuals and prolonged recovery times. Obese individuals exhibit impaired immune organ function, decreased immune cell activity, disrupted metabolism characterized by mitochondrial dysfunction, and an imbalance in gut microbiota associated with intestinal mucosal barrier damage. The gut microbiota and their metabolic composition in obese patients differ from those in non-obese individuals, potentially promoting viral replication and exacerbating disease severity. These factors collectively contribute to more severe tissue damage and heightened immune responses in obese patients during influenza infection. Therefore, understanding the impact of obesity on influenza virus infection dynamics enables the development of strategies promoting healthy lifestyles to manage body weight and enhance immunity against viral infections. Additionally, given that this special population may not respond optimally to antimicrobial drugs and vaccination, it is necessary to consider how treatment strategies for this group are managed. This review illustrates findings concerning the impact of obesity on the immune response to influenza virus infection, including potential underlying mechanisms.

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肥胖对流感病毒免疫的影响:肠道微生物群、机制和新的治疗策略。
肥胖影响着全球数百万人,更深入地了解其相关的生理障碍对于解决关键的公共卫生问题至关重要。已经证明,流感病毒具有巨大的全球流行潜力,在肥胖个体中观察到较高的发病率,并且恢复时间较长。肥胖个体表现为免疫器官功能受损,免疫细胞活性下降,代谢紊乱,以线粒体功能障碍为特征,肠道微生物群失衡与肠粘膜屏障损伤相关。肥胖患者的肠道微生物群及其代谢组成与非肥胖个体不同,这可能促进病毒复制并加剧疾病严重程度。这些因素共同导致肥胖患者在流感感染期间更严重的组织损伤和免疫反应增强。因此,了解肥胖对流感病毒感染动态的影响,有助于制定促进健康生活方式的策略,以控制体重并增强对病毒感染的免疫力。此外,鉴于这一特殊人群可能对抗菌药物和疫苗接种反应不佳,有必要考虑如何管理这一群体的治疗策略。这篇综述阐述了肥胖对流感病毒感染免疫反应的影响,包括潜在的潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.80
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0.00%
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审稿时长
6 weeks
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