Association between prediabetes and thyroid cancer risk: A meta-analysis.

0 MEDICINE, RESEARCH & EXPERIMENTAL
Yi Shen, Xiaoen Li, Yupan Chen, Xujie Han, Rongli Xie
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Abstract

Prediabetes, characterized by intermediate hyperglycemia, is increasingly prevalent worldwide. While diabetes has been associated with a heightened risk of various cancers, the relationship between prediabetes and thyroid cancer remains ambiguous. This meta-analysis sought to assess whether prediabetes correlates with an elevated incidence of thyroid cancer. A systematic literature search was conducted across PubMed, Embase, Web of Science, Wanfang, and CNKI to identify longitudinal studies that compared the incidence of thyroid cancer in individuals with prediabetes to those with normoglycemia. Risk ratios (RRs) with 95% confidence intervals (CIs) were aggregated using a random-effects model. Subgroup and sensitivity analyses were performed to identify potential effect modifiers. Six prospective cohort studies, encompassing 5,743,849 participants, were included in the analysis. Overall, prediabetes was not significantly correlated with thyroid cancer incidence (RR = 1.04; 95% CI: 0.98-1.11; p = 0.23; I² = 53%). Subgroup analyses revealed no significant variations based on age, sex, region, follow-up duration, or definition of prediabetes. Notably, a significant association was identified in studies utilizing cancer registries or validated clinical diagnoses (RR = 1.29; 95% CI: 1.04-1.60), in contrast to studies relying solely on ICD-10 codes (RR = 1.01; 95% CI: 0.98-1.05; p for subgroup difference = 0.03). In conclusion, prediabetes was not linked to a significantly increased risk of thyroid cancer overall. However, a potential association was noted in studies employing clinically validated cancer diagnoses. These findings, derived from observational cohorts, should be interpreted cautiously, and further prospective research is necessary to elucidate any causal relationship.

前驱糖尿病与甲状腺癌风险之间的关系:一项荟萃分析。
以中度高血糖为特征的前驱糖尿病在世界范围内日益普遍。虽然糖尿病与各种癌症的风险增加有关,但前驱糖尿病与甲状腺癌之间的关系仍不明确。本荟萃分析旨在评估糖尿病前期是否与甲状腺癌发病率升高相关。对PubMed、Embase、Web of Science、万方和CNKI进行了系统的文献检索,以确定比较糖尿病前期个体与血糖正常个体甲状腺癌发病率的纵向研究。采用随机效应模型汇总95%置信区间的风险比(rr)。进行亚组分析和敏感性分析,以确定潜在的效果调节剂。六项前瞻性队列研究,包括5,743,849名参与者,被纳入分析。总体而言,前驱糖尿病与甲状腺癌发病率无显著相关性(RR = 1.04; 95% CI: 0.98-1.11; p = 0.23; I²= 53%)。亚组分析显示,年龄、性别、地区、随访时间或前驱糖尿病定义没有显著差异。值得注意的是,与仅依赖ICD-10代码的研究(RR = 1.01; 95% CI: 0.98-1.05;亚组差异p = 0.03)相比,利用癌症登记或经过验证的临床诊断的研究发现了显著的相关性(RR = 1.29; 95% CI: 1.04-1.60)。总的来说,前驱糖尿病与甲状腺癌风险的显著增加无关。然而,在采用临床验证的癌症诊断的研究中指出了一种潜在的关联。这些来自观察性队列的发现应谨慎解释,需要进一步的前瞻性研究来阐明任何因果关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.10
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