Cerebral palsy predictive value of 4 months-AIMS in newborns with hypoxic-ischaemic encephalopathy.

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology Pub Date : 2025-08-14 DOI:10.1016/j.pedneo.2025.08.001

William Rozalen, Elana F Pinchefsky, Jessica Gennaoui, Annie Veilleux, Bohdana Marandyuk, Anne-Monique Nuyt, Matsanga Leyila Kaseka, Gregory A Lodygensky, Béatrice Desnous

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引用次数: 0

Abstract

Aim: Predicting motor outcomes in hypoxic-ischaemic encephalopathy (HIE) is challenging. We aimed to assess the value of the four-month Alberta Infant Motor Scale (4M-AIMS) in predicting motor development at 18 months of age.

Method: A retrospective cohort study was conducted at Sainte-Justine University Hospital Centre (Canada), including patients with hypoxic-ischemic encephalopathy (HIE) who underwent therapeutic hypothermia between 2009 and 2016. Neurodevelopmental follow-ups were conducted at two and four months with the AIMS, and motor outcomes were classified at 18 months according to the Gross Motor Function Classification System. Ordinal regression was used to assess the predictive value of AIMS scores and brain MRI for motor outcome.

Results: Of the 52 newborns included: 16 children (31 %) had normal motor development, 25 (48 %) displayed motor delays, and 11 patients (21 %) had cerebral palsy. Forty-one (79 %) infants had an abnormal 4M-AIMS score (below the 10th percentile). Early brain MRI and 4M-AIMS scores were both predictive of altered motor outcomes (χ² = 6.1, p-value = 0.013 and χ² = 4.9, p-value = 0.029, respectively). A normal four-month AIMS assessment is considered a reliable indicator for excluding a future cerebral palsy.

Interpretation: Complementary assessment with brain MRI and 4M-AIMS with a score below the 0th percentile provides accurate prediction of motor outcomes at 18 months.

Short title: Cerebral Palsy predictive value of AIMS.

查看原文本刊更多论文

新生儿缺氧缺血性脑病4个月aims对脑瘫的预测价值。

目的：预测缺氧缺血性脑病（HIE）的运动预后具有挑战性。我们的目的是评估四个月艾伯塔省婴儿运动量表（4M-AIMS）在预测18个月大的运动发育方面的价值。方法：在加拿大圣贾斯汀大学医院中心进行回顾性队列研究，纳入2009 - 2016年间接受过低温治疗的缺氧缺血性脑病（HIE）患者。使用AIMS在2个月和4个月时进行神经发育随访，并根据大运动功能分类系统在18个月时对运动结果进行分类。采用有序回归评估AIMS评分和脑MRI对运动预后的预测价值。结果：52例新生儿中，16例（31%）运动发育正常，25例（48%）运动发育迟缓，11例（21%）脑瘫。41例（79%）婴儿的4M-AIMS评分异常（低于第10百分位）。早期脑MRI和4M-AIMS评分均可预测运动预后的改变（χ2 = 6.1， p值= 0.013;χ2 = 4.9， p值= 0.029）。正常的4个月AIMS评估被认为是排除未来脑瘫的可靠指标。解释：脑MRI和4M-AIMS评分低于第0百分位的辅助评估可以准确预测18个月时的运动预后。短标题：AIMS对脑瘫的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatrics and Neonatology PEDIATRICS-

CiteScore

3.10

自引率

0.00%

发文量

170

审稿时长

48 days

期刊介绍： Pediatrics and Neonatology is the official peer-reviewed publication of the Taiwan Pediatric Association and The Society of Neonatology ROC, and is indexed in EMBASE and SCOPUS. Articles on clinical and laboratory research in pediatrics and related fields are eligible for consideration.