{"title":"Unveiling success: determinants of a successful haematopoietic stem cell transplant: a case report.","authors":"Tariq Mahmood Satti, Rimsha Jafar, Zoya Habib, Koukab Ejaz, Zulqarnain Arif, Fahad Haider Shah","doi":"10.47391/JPMA.21537","DOIUrl":null,"url":null,"abstract":"<p><p>Patients with beta thalassemia major can make an uneventful and miraculous recovery after bone marrow transplantation despite lacking a sibling donor. The once widely accepted belief that only a transplant received from a sibling or mother would lead to a successful outcome has been challenged by the advent of new approaches and drugs. We present the case of a 15-yearold girl who received stem cells from her father and, despite suffering an attack of acute graft versus host disease (aGVHD) and depression, still managed to achieve a 100% success rate. This report highlights the importance of factors other than the source of stem cells in evaluating the patient's outcome and the lack of awareness about this disease even among the literate population in our country.</p>","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 8","pages":"1284-1286"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Pakistan Medical Association","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47391/JPMA.21537","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Patients with beta thalassemia major can make an uneventful and miraculous recovery after bone marrow transplantation despite lacking a sibling donor. The once widely accepted belief that only a transplant received from a sibling or mother would lead to a successful outcome has been challenged by the advent of new approaches and drugs. We present the case of a 15-yearold girl who received stem cells from her father and, despite suffering an attack of acute graft versus host disease (aGVHD) and depression, still managed to achieve a 100% success rate. This report highlights the importance of factors other than the source of stem cells in evaluating the patient's outcome and the lack of awareness about this disease even among the literate population in our country.
期刊介绍：
Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.
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