{"title":"Pharmacosimilars In Obesity Medicine: Informed Choice, Appropriate Choice.","authors":"Sanjay Kalra, Amandeep Singh, Nitin Kapoor","doi":"10.47391/JPMA.25-61","DOIUrl":null,"url":null,"abstract":"<p><p>Newer developments in endocrine pharmacology have blurred the distinction between biosimilars and generics. The originator semaglutide, for example, is a biologically active compound, but later versions are chemically synthesized generics. Tirzepatide is a synthetic polypeptide. These molecules are marketed in different strengths and delivery devices across the world. The word 'pharmaco-similar' can be used to describe both biosimilar and generic versions of originator peptidebased medications. This communication suggests a useful framework which assists in sharing information and reaching an informed decision regarding choice of anti-obesity medication. This approval process and status, evidence and experience base, economic factors, rules related to interchange/substitution, robustness of cold chain, and availability of uninterrupted supply all influence this decision.</p>","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 8","pages":"1293-1295"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Pakistan Medical Association","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47391/JPMA.25-61","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Newer developments in endocrine pharmacology have blurred the distinction between biosimilars and generics. The originator semaglutide, for example, is a biologically active compound, but later versions are chemically synthesized generics. Tirzepatide is a synthetic polypeptide. These molecules are marketed in different strengths and delivery devices across the world. The word 'pharmaco-similar' can be used to describe both biosimilar and generic versions of originator peptidebased medications. This communication suggests a useful framework which assists in sharing information and reaching an informed decision regarding choice of anti-obesity medication. This approval process and status, evidence and experience base, economic factors, rules related to interchange/substitution, robustness of cold chain, and availability of uninterrupted supply all influence this decision.
期刊介绍：
Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.
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