{"title":"Network analysis of beta gene (HBB) haplotypes related to Hb S (β6 Glu → Val) in Denizli, Turkiye.","authors":"Onur Ozturk","doi":"10.47391/JPMA.21639","DOIUrl":null,"url":null,"abstract":"<p><p>Numerous haplotypes related to the haemoglobin S mutation have been diagnosed worldwide and in the Denizli region of Türkiye. These subgroup haplotypes include Benin, Arab-Indian, Senegal, Bantu, Algeria, Cameroon, Central African Republic, Saudi and various other varieties. The current study was planned to determine the formation periods and network linkage relationships of genetic variations linked to haemoglobin S in the Denizli area and other geographical regions. The haplotype data was processed using Network software to calculate possible links between haplotypes and their formation dates. The results uphold the possibility that the haemoglobin S mutation may have come to the area through migratory pathways. According to analysis, the Benin haplotype historically formed first, followed by the Senegal and Arab-Indian haplotypes. These findings indicate that the haemoglobin S mutation might have reached the Mediterranean area long before the Silk Route migrations ≈ 2,000 years ago.</p>","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 8","pages":"1262-1266"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Pakistan Medical Association","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47391/JPMA.21639","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Numerous haplotypes related to the haemoglobin S mutation have been diagnosed worldwide and in the Denizli region of Türkiye. These subgroup haplotypes include Benin, Arab-Indian, Senegal, Bantu, Algeria, Cameroon, Central African Republic, Saudi and various other varieties. The current study was planned to determine the formation periods and network linkage relationships of genetic variations linked to haemoglobin S in the Denizli area and other geographical regions. The haplotype data was processed using Network software to calculate possible links between haplotypes and their formation dates. The results uphold the possibility that the haemoglobin S mutation may have come to the area through migratory pathways. According to analysis, the Benin haplotype historically formed first, followed by the Senegal and Arab-Indian haplotypes. These findings indicate that the haemoglobin S mutation might have reached the Mediterranean area long before the Silk Route migrations ≈ 2,000 years ago.
期刊介绍：
Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.
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