Trends and Prevalence of Modifiable Risk Factors for Birth Defects Among U.S. Women of Reproductive Age: National Health and Nutrition Examination Survey 2007 to March 2020.

IF 4.5 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Arick Wang, Lauren H Zauche, Krista S Crider, Cara T Mai, Yan Ping Qi, Lorraine F Yeung, Jennifer L Williams
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引用次数: 0

Abstract

Introduction: Congenital heart defects, orofacial clefts, and neural tube defects share similar modifiable risk factors. The prevalence and trends of risk factors for these selected birth defects were assessed among nonpregnant, nonlactating women of reproductive age (aged 12-49 years) in the U.S.

Methods: Cross-sectional data from the National Health and Nutrition Examination Survey 2007-March 2020 were analyzed in fall 2024. Demographics, BMI, household food security, folic acid supplement use, usual intake of dietary folate and vitamin B12, concentrations for serum and red blood cell folate, serum vitamin B12, serum cotinine (smoking exposure), and diabetes status were reported. Weighted percentages of prevalence of risk factors with 95% CIs were calculated using the survey package in R to account for clustered sampling.

Results: Among 5,374 women of reproductive age, approximately 66.4% (95% CI=64.3, 68.4) had at least 1 known modifiable risk factor: 6.7% (95% CI=5.7, 7.6) reported very low food security, 33.8% (95% CI=32.2, 35.4) had obesity, 4.8% (95% CI=4.0, 5.5) had diabetes, 18.8% (95% CI=17.2, 20.4) had smoking exposure, and 19.5% (95% CI=17.8, 21.1) had red blood cell folate concentrations below the threshold (748 nmol/L) for optimal neural tube defect prevention. Over the time studied, the percentage of women of reproductive age with at least 1 risk factor rose from 65.3% (95% CI=62.1, 68.4) to 69.5% (95% CI=65.4, 73.9; p=0.08).

Conclusions: Approximately 2 of 3 women of reproductive age in the U.S. have pre-existing modifiable risk factors for birth defects. Implementation of preconception health care could help reduce the prevalence of known risk factors and improve birth outcomes.

美国育龄妇女出生缺陷可改变风险因素的趋势和流行:2007年至2020年3月的国家健康和营养检查调查
简介:先天性心脏缺陷、口面裂和神经管缺陷具有相似的可改变的危险因素。在美国非怀孕、非哺乳期育龄妇女(12-49岁)中,评估了这些选定的出生缺陷的危险因素的患病率和趋势。方法:在2024年秋季分析了2007年3月至2020年3月全国健康与营养检查调查的横断面数据。报告了人口统计、体重指数、家庭食品安全、叶酸补充剂使用情况、日常饮食中叶酸和维生素B12的摄入量、血清和红细胞叶酸浓度、血清维生素B12、血清可替宁(吸烟暴露)和糖尿病状况。使用R中的调查包计算具有95% ci的危险因素流行率的加权百分比,以考虑聚类抽样。结果:在5374名育龄妇女中,大约66.4% (95% CI=64.3, 68.4)至少有一个已知的可改变的危险因素:6.7% (95% CI=5.7, 7.6)报告食物安全水平很低,33.8% (95% CI=32.2, 35.4)患有肥胖,4.8% (95% CI=4.0, 5.5)患有糖尿病,18.8% (95% CI=17.2, 20.4)有吸烟暴露,19.5% (95% CI=17.8, 21.1)红细胞叶酸浓度低于最佳神经管缺陷预防阈值(748 nmol/L)。在研究期间,育龄妇女至少有一种危险因素的比例从65.3% (95% CI=62.1, 68.4)上升到69.5% (95% CI=65.4, 73.9; p=0.08)。结论:在美国,大约三分之二的育龄妇女存在先天缺陷的可改变危险因素。实施孕前保健有助于减少已知危险因素的流行,并改善生育结果。
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来源期刊
American Journal of Preventive Medicine
American Journal of Preventive Medicine 医学-公共卫生、环境卫生与职业卫生
CiteScore
8.60
自引率
1.80%
发文量
395
审稿时长
32 days
期刊介绍: The American Journal of Preventive Medicine is the official journal of the American College of Preventive Medicine and the Association for Prevention Teaching and Research. It publishes articles in the areas of prevention research, teaching, practice and policy. Original research is published on interventions aimed at the prevention of chronic and acute disease and the promotion of individual and community health. Of particular emphasis are papers that address the primary and secondary prevention of important clinical, behavioral and public health issues such as injury and violence, infectious disease, women''s health, smoking, sedentary behaviors and physical activity, nutrition, diabetes, obesity, and substance use disorders. Papers also address educational initiatives aimed at improving the ability of health professionals to provide effective clinical prevention and public health services. Papers on health services research pertinent to prevention and public health are also published. The journal also publishes official policy statements from the two co-sponsoring organizations, review articles, media reviews, and editorials. Finally, the journal periodically publishes supplements and special theme issues devoted to areas of current interest to the prevention community.
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