Jie Hou, Hui Feng, Minheng Zhang, Dayi Wang, Haixia Fan
{"title":"Hotspots and future trends of male breast cancer: a global perspective.","authors":"Jie Hou, Hui Feng, Minheng Zhang, Dayi Wang, Haixia Fan","doi":"10.1007/s12094-025-04026-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Male breast cancer (MBC), a rare disease accounting for less than 1% of all cancers in men and approximately 1% of all breast cancers globally, exhibits unique biological and clinical characteristics that distinguish it from female breast cancer (FBC). To identify the latest developments and trends in MBC research, we performed a comprehensive analysis of relevant literature and generated visual representations of the data. Building on these outcomes, we delve into the insights gained, aiming to enhance the ongoing comprehension of MBC.</p><p><strong>Methods: </strong>We conducted a search of the Web of Science Core Collection (WoSCC) for English-language articles and reviews on MBC published from 1982 to 2024. Following a rigorous dual-researcher screening process, we refined the dataset to 6802 relevant records. Subsequently, we employed Microsoft Excel for initial data organization and processing. For in-depth analysis and visualization of journal, country/region, author/institution trends, as well as keyword patterns, we utilized a combination of R Package, VOSviewer, and CiteSpace. This multi-tool approach enabled us to extract and present meaningful insights from the data.</p><p><strong>Results: </strong>MBC research has risen since 1996, with a 2024 peak at 503 publications, reflecting advances like BRCA1/2 gene discoveries. The USA leads in publications and citations, with North America and Europe being the most collaborative regions. Key journals include Breast Cancer Research and Treatment, and leading contributors are Ottini, Laura and Van Diest, Paul J. Research focuses on MBC's genetic links (e.g. BRCA mutations) and clinical features, with emerging topics like precision medicine and immunotherapy.</p><p><strong>Conclusion: </strong>MBC research has grown but remains concentrated in high-income countries. Future efforts should explore MBC's unique biology, improve diagnostic/therapeutic strategies, and involve global, interdisciplinary collaboration to enhance patient outcomes.</p>","PeriodicalId":50685,"journal":{"name":"Clinical & Translational Oncology","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical & Translational Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12094-025-04026-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Male breast cancer (MBC), a rare disease accounting for less than 1% of all cancers in men and approximately 1% of all breast cancers globally, exhibits unique biological and clinical characteristics that distinguish it from female breast cancer (FBC). To identify the latest developments and trends in MBC research, we performed a comprehensive analysis of relevant literature and generated visual representations of the data. Building on these outcomes, we delve into the insights gained, aiming to enhance the ongoing comprehension of MBC.
Methods: We conducted a search of the Web of Science Core Collection (WoSCC) for English-language articles and reviews on MBC published from 1982 to 2024. Following a rigorous dual-researcher screening process, we refined the dataset to 6802 relevant records. Subsequently, we employed Microsoft Excel for initial data organization and processing. For in-depth analysis and visualization of journal, country/region, author/institution trends, as well as keyword patterns, we utilized a combination of R Package, VOSviewer, and CiteSpace. This multi-tool approach enabled us to extract and present meaningful insights from the data.
Results: MBC research has risen since 1996, with a 2024 peak at 503 publications, reflecting advances like BRCA1/2 gene discoveries. The USA leads in publications and citations, with North America and Europe being the most collaborative regions. Key journals include Breast Cancer Research and Treatment, and leading contributors are Ottini, Laura and Van Diest, Paul J. Research focuses on MBC's genetic links (e.g. BRCA mutations) and clinical features, with emerging topics like precision medicine and immunotherapy.
Conclusion: MBC research has grown but remains concentrated in high-income countries. Future efforts should explore MBC's unique biology, improve diagnostic/therapeutic strategies, and involve global, interdisciplinary collaboration to enhance patient outcomes.
期刊介绍：
Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
